Document Detail


Immunosuppressive effects of rubidatum in mice.
MedLine Citation:
PMID:  11501189     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To study the effect of rubidatum (Rub) on immune function in normal mice. METHODS: Serum lysozyme concentration (SLC) was measured using micrococcus lysodiekticus as a substrate. Delayed type hypersensitivity (DTH) was determined by measuring the thickness of the right hind footpad 24 h after the injection of 1 x 10(8) washed sRBC (50 microL 10% sRBC). Serum hemolysin concentration was determined by OD measuring at A540 after the serum was treated with 2-mercaptoethanol. Phagocytic function of peripheral leukocyte (Leu) were determined by the incorporated radioactivity of [3H]TdR. The hemolytic activity of plaque forming cell (PFC) was determined by measuring the lymphocytemediated hemolysis of sheep red blood cell in vitro. T- and B-lymphocyte transformation (TLT and BLT) were induced by phytohemagglutinin (PHA) and lipopolysacharide (LPS) respectively and measured by the incorporation of [3H]TdR. RESULTS: Rub 125, 500, 2000 mg.kg-1.d-1 p.o. to BALB/c (or NIH) mice decreased the SLC; inhibited the phagocytosing functions of peripheral leukocytes; diminished the hemolytic activity of PFC; decreased the HC50; inhibited the DTH reaction; and showed inhibitory effects on TLT and BLT. CONCLUSION: Rub has immunosuppressive effects on immune system in mice by affecting M phi, T, and B lymphocyte, which suggests that Rub has inhibitory effects on both nonspecific and specific immune function.
Authors:
S L Yang; F Liu; H Zhang; Q L Dou
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta pharmacologica Sinica     Volume:  21     ISSN:  1671-4083     ISO Abbreviation:  Acta Pharmacol. Sin.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2001-08-14     Completed Date:  2001-10-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  100956087     Medline TA:  Acta Pharmacol Sin     Country:  China    
Other Details:
Languages:  eng     Pagination:  765-8     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, 474th Hospital, PLA, Urumqi 830011, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Hemolytic Plaque Technique
Hypersensitivity, Delayed
Immunosuppressive Agents / pharmacology*
Leukocytes / physiology
Lymphocyte Activation / drug effects
Male
Mice
Mice, Inbred BALB C
Muramidase / blood
Naphthols / pharmacology*
Phagocytosis / drug effects
Chemical
Reg. No./Substance:
0/Immunosuppressive Agents; 0/Naphthols; 59883-07-7/rubidate; EC 3.2.1.17/Muramidase

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