Document Detail

Immunosuppressive effects of four trichothecene mycotoxins.
MedLine Citation:
PMID:  2262045     Owner:  NLM     Status:  MEDLINE    
The trichothecenes are a family of mycotoxins contaminating some food and feeds. We have studied the inhibitory effect of four of them including less toxic compounds: T-2 toxin, DAS, DON and Trichodermin, on normal human peripheral blood lymphocytes and murine splenic lymphocytes. The results show that even for the least toxic compound, inhibiting concentrations can be realised in the blood by common alimentary contamination.
C Mekhancha-Dahel; C Lafarge-Frayssinet; C Frayssinet
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Food additives and contaminants     Volume:  7 Suppl 1     ISSN:  0265-203X     ISO Abbreviation:  Food Addit Contam     Publication Date:  1990  
Date Detail:
Created Date:  1991-02-07     Completed Date:  1991-02-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8500474     Medline TA:  Food Addit Contam     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  S94-6     Citation Subset:  IM    
INATAA, Université de Constantine, Algeria.
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MeSH Terms
Cells, Cultured
DNA / biosynthesis
Food Contamination*
Immune Tolerance / drug effects
Lymphocytes / drug effects*
Mice, Inbred BALB C
Species Specificity
Trichothecenes / immunology,  pharmacology*
Reg. No./Substance:
0/Trichothecenes; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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