Document Detail

Immunosuppressive drugs and their effects.
MedLine Citation:
PMID:  8016474     Owner:  NLM     Status:  MEDLINE    
The growing success of organ transplantation for the treatment of diabetes mellitus and end-stage renal, heart, lung, and liver disease is attributable, in part, to improvements in immunosuppressive regimens. This article reviews the immune response and the mechanism by which many immunosuppressants exert their effects. Immunosuppressants discussed include azathioprine, glucocorticoids, cyclosporine A, cyclosporine G, FK506, rapamycin, mycophenolic acid, mycophenolate mofetil (RS-61443), mizoribine (bredinin), brequinar sodium, and deoxyspergualine. The efficacy and nonspecificity of these agents has led to significant side effects from their use, which can be predicted based on their mechanisms of action. The development and use of more specific immunosuppressants or the design of protocols, which would induce organ tolerance, may result in long-term organ survival without infectious or malignant complications.
K R Superdock; J H Helderman
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in respiratory infections     Volume:  8     ISSN:  0882-0546     ISO Abbreviation:  Semin Respir Infect     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1994-07-26     Completed Date:  1994-07-26     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8700961     Medline TA:  Semin Respir Infect     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  152-9     Citation Subset:  IM    
Division of Nephrology, Vanderbilt University Medical Center, Nashville.
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MeSH Terms
Clinical Protocols
Cytokines / immunology
Graft Rejection / drug therapy*,  immunology
Graft Survival / immunology
Immunity, Cellular / immunology
Immunosuppressive Agents / immunology*,  therapeutic use*
Lymphocyte Activation / immunology
T-Lymphocytes, Cytotoxic / immunology
Transplantation Immunology / drug effects*,  immunology*
Reg. No./Substance:
0/Cytokines; 0/Immunosuppressive Agents

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