Document Detail

Immunosuppressive activity of rhesus monkey pregnancy serum.
MedLine Citation:
PMID:  6452817     Owner:  NLM     Status:  MEDLINE    
Normal pregnancy serum from the rhesus monkey was found to have immunosuppressive activity. Using two-way stimulation, the mixed lymphocyte response was suppressed as much as 80%. Control serum from nonpregnant females was not suppressive. The inhibiting factor was found to have the following characteristics: (1) it was nonspecific in activity; (2) it inhibited the mixed lymphocyte response 20% at in vitro concentrations of 1%; (3) it was heat stable (56 degrees C for 30 minutes) and nondialyzable; (4) it was present in both the IgM- and IgG-containing fractions of pregnancy serum; (5) it was detected in postpartum and second and third trimester serum; and (6) it was at low levels or absent from the serum of two pregnancies which terminated in unexplained stillbirths.
L R Ellingsworth; L G Hayashi; B I Osburn; C A Holmberg
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  139     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1981 Apr 
Date Detail:
Created Date:  1981-06-13     Completed Date:  1981-06-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  932-6     Citation Subset:  AIM; IM    
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MeSH Terms
B-Lymphocytes / immunology
Fetus / immunology
Immunoglobulin M / immunology
Immunosuppressive Agents / blood*
Lymphocyte Culture Test, Mixed
Macaca mulatta
Pregnancy, Animal*
Grant Support
Reg. No./Substance:
0/Immunoglobulin M; 0/Immunosuppressive Agents

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