Document Detail

Immunosuppressive activity of a purified spleen extract (lymphocytic chalone?) is not due to polyamines spermine and spermidine.
MedLine Citation:
PMID:  158396     Owner:  NLM     Status:  MEDLINE    
Spermine, spermidine and a purified spleen extract (PSE) have been compared in vivo in these three tests: hemolytic plaque forming capacity in sensitized mice, delayed hypersensitivity reaction and 3H-thymidine incorporation into various tissue cells. The results obtained demonstrated that the immunosuppressive activity of PSE cannot be attributed to those polyamines. Ion exchange analysis of PSE before and after acid hydrolysis confirmed the absence of free and/or bound polyamines in the studied extract.
M Lenfant; L di Giusto; D L Oleson; E Garcia-Giralt; E Mayadoux; V Villanueva; R C Adlakha
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomedicine / [publiée pour l'A.A.I.C.I.G.]     Volume:  31     ISSN:  0300-0893     ISO Abbreviation:  Biomedicine     Publication Date:  1979 Jul 
Date Detail:
Created Date:  1979-12-20     Completed Date:  1979-12-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0361342     Medline TA:  Biomedicine     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  110-3     Citation Subset:  IM    
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MeSH Terms
DNA / biosynthesis
Dermatitis, Contact / immunology
Growth Inhibitors
Hemolytic Plaque Technique
Mice, Inbred DBA
Spermidine / immunology*
Spermine / immunology*
Spleen / immunology*
Thymidine / metabolism
Tissue Extracts / pharmacology
Reg. No./Substance:
0/Growth Inhibitors; 0/Tissue Extracts; 124-20-9/Spermidine; 50-89-5/Thymidine; 71-44-3/Spermine; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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