Document Detail

Immunosuppressive HLA-G molecule is upregulated in alveolar epithelial cells after influenza A virus infection.
MedLine Citation:
PMID:  19664669     Owner:  NLM     Status:  MEDLINE    
Influenza virus type A (IAV) infections constitute an important economic burden and raise health-care problems. Host defense mechanisms usually clear IAV infections after a few days by exploiting a variety of cellular immune responses. However, increasing the production of immunosubversive molecules is a mechanism by which viruses escape host surveillance. In this regard, the nonclassical HLA class I molecule HLA-G displays strong tolerogenic properties. We show here that several strains of IAV differently upregulate HLA-G expression, at both the mRNA and protein levels, in alveolar epithelial cells. Thus the virulence of IAV may be caused by the capability of different strains to upregulate HLA-G allowing their escape from host immune responses.
Fanny LeBouder; Khaled Khoufache; Catherine Menier; Yassmina Mandouri; Mahmoud Keffous; Nathalie Lejal; Ir??ne Krawice-Radanne; Edgardo D Carosella; Nathalie Rouas-Freiss; B??atrice Riteau
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-05
Journal Detail:
Title:  Human immunology     Volume:  70     ISSN:  1879-1166     ISO Abbreviation:  Hum. Immunol.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-13     Completed Date:  2010-01-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8010936     Medline TA:  Hum Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1016-9     Citation Subset:  IM    
Unit?? de Virologie et Immunologie Mol??culaires, UR 892 INRA, Domaine de Vilvert, 78352 Jouy-en-Josas, France.
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MeSH Terms
Cell Line
HLA Antigens / analysis,  biosynthesis*
Histocompatibility Antigens Class I / analysis,  biosynthesis*
Immune Tolerance*
Influenza A virus / immunology*
Influenza, Human / immunology*
Pulmonary Alveoli / immunology*,  virology
RNA, Messenger / immunology,  metabolism
Respiratory Mucosa / immunology,  virology
Reg. No./Substance:
0/HLA Antigens; 0/HLA-G antigen; 0/Histocompatibility Antigens Class I; 0/RNA, Messenger

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