| Immunosuppressive HLA-G molecule is upregulated in alveolar epithelial cells after influenza A virus infection. | |
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MedLine Citation:
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PMID: 19664669 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Influenza virus type A (IAV) infections constitute an important economic burden and raise health-care problems. Host defense mechanisms usually clear IAV infections after a few days by exploiting a variety of cellular immune responses. However, increasing the production of immunosubversive molecules is a mechanism by which viruses escape host surveillance. In this regard, the nonclassical HLA class I molecule HLA-G displays strong tolerogenic properties. We show here that several strains of IAV differently upregulate HLA-G expression, at both the mRNA and protein levels, in alveolar epithelial cells. Thus the virulence of IAV may be caused by the capability of different strains to upregulate HLA-G allowing their escape from host immune responses. |
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Authors:
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Fanny LeBouder; Khaled Khoufache; Catherine Menier; Yassmina Mandouri; Mahmoud Keffous; Nathalie Lejal; Ir??ne Krawice-Radanne; Edgardo D Carosella; Nathalie Rouas-Freiss; B??atrice Riteau |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-08-05 |
Journal Detail:
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Title: Human immunology Volume: 70 ISSN: 1879-1166 ISO Abbreviation: Hum. Immunol. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-13 Completed Date: 2010-01-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8010936 Medline TA: Hum Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 1016-9 Citation Subset: IM |
Affiliation:
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Unit?? de Virologie et Immunologie Mol??culaires, UR 892 INRA, Domaine de Vilvert, 78352 Jouy-en-Josas, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Line Dogs HLA Antigens / analysis, biosynthesis* Histocompatibility Antigens Class I / analysis, biosynthesis* Humans Immune Tolerance* Influenza A virus / immunology* Influenza, Human / immunology* Pulmonary Alveoli / immunology*, virology RNA, Messenger / immunology, metabolism Respiratory Mucosa / immunology, virology Up-Regulation |
| Chemical | |
Reg. No./Substance:
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0/HLA Antigens; 0/HLA-G antigen; 0/Histocompatibility Antigens Class I; 0/RNA, Messenger |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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