| Immunosuppression and parasitic diseases: experimental Schistosomiasis mansoni. | |
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MedLine Citation:
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PMID: 10436644 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cyclosporin A is an immunosuppressive agent of clinical relevance and also possesses a potent antiparasitic effect. In organ transplants and tissue grafts, this agent is frequently used in combination with hydrocortisone. Thus the reciprocal effects of these immunosuppressants on experimental Schistosomiasis mansoni were studied. Mice were subcutaneously inoculated with Schistosoma mansoni cercariae, and infected animals which were treated or not with oxaminiquine were subsequently immunosuppressed or not. Potentially fatal exacerbations of parasitemia and parasitism were observed in immunosuppressed animals, in contrast to control animals, suggesting that in transplanted patients an adverse Schistosomiasis may be evolved. Despite the prominent immunomodulation effect, these drugs showed a moderate antiparasitic effect, complementing the schistosomicidal activity of oxamniquine. This effect also seems favorable in the antischistosomal treatment of transplanted patients with S. mansoni infection. |
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Authors:
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C Gargione; S A Vellosa; S Hoshino-Shimizu; M Okumura; S G Chiodelle |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Revista do Hospital das Clínicas Volume: 53 ISSN: 0041-8781 ISO Abbreviation: Rev Hosp Clin Fac Med Sao Paulo Publication Date: 1998 May-Jun |
Date Detail:
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Created Date: 1999-11-22 Completed Date: 1999-11-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0415246 Medline TA: Rev Hosp Clin Fac Med Sao Paulo Country: BRAZIL |
Other Details:
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Languages: eng Pagination: 122-8 Citation Subset: IM |
Affiliation:
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Instituto Adolfo Lutz, Universidade de São Paulo, Brasil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Inflammatory Agents / pharmacology* Cyclosporine / pharmacology* Hydrocortisone / pharmacology* Immunosuppression* Immunosuppressive Agents / pharmacology* Liver / pathology Male Mice Oxamniquine / pharmacology* Schistosoma mansoni / drug effects* Schistosomiasis mansoni / immunology* Schistosomicides / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Immunosuppressive Agents; 0/Schistosomicides; 21738-42-1/Oxamniquine; 50-23-7/Hydrocortisone; 59865-13-3/Cyclosporine |
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