Document Detail


Immunosuppression in patients with severe acute pancreatitis.
MedLine Citation:
PMID:  16988767     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: In severe acute pancreatitis (SAP), immunologic impairment in the early phase may be linked to subsequent infectious complications. In this study, immunologic alterations in patients with SAP were analyzed, and immunologic parameters related to infectious complications were clarified. METHODS: A total of 101 patients with SAP were analyzed retrospectively. Various immunologic parameters on admission were analyzed and compared between the infection group and noninfection group during SAP. Furthermore, chronologic change in the lymphocyte count was investigated, and its utility for predicting infection was compared with conventional scoring systems. RESULTS: Serum immunoglobulin G (IgG), serum IgM, lymphokine-activated killer cell activity, and natural killer cell activity were low, and the incidence of abnormally low values was 50.0%, 65.0%, 45.5%, and 42.4%, respectively. Serum complement factor 3 was significantly negatively correlated with the APACHE II score. The lymphocyte count was decreased below the normal range, and was significantly negatively correlated with the APACHE II score. CD4-, CD8-, and CD20-positive lymphocyte counts were below the normal range, and CD4- and CD8-positive lymphocyte counts were significantly lower in the infection group. The lymphocyte count on day 14 after admission was significantly lower in the infection group and was more useful for predicting infection than conventional scoring systems. CONCLUSIONS: Immunosuppression occurs from the early phase in SAP, and quantitative impairment of lymphocytes, mainly T lymphocytes, may be closely related to infectious complications during SAP. CD4- and CD8-positive lymphocyte counts on admission and the lymphocyte count on day 14 after admission may be useful for predicting infection.
Authors:
Takashi Ueda; Yoshifumi Takeyama; Takeo Yasuda; Makoto Shinzeki; Hidehiro Sawa; Takahiro Nakajima; Tetsuo Ajiki; Yasuhiro Fujino; Yasuyuki Suzuki; Yoshikazu Kuroda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of gastroenterology     Volume:  41     ISSN:  0944-1174     ISO Abbreviation:  J. Gastroenterol.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-09-21     Completed Date:  2006-12-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9430794     Medline TA:  J Gastroenterol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  779-84     Citation Subset:  IM    
Affiliation:
Department of Gastroenterological Surgery, Kobe University Graduate School of Medical Sciences, Chuo-ku, Kobe 650-0017, Japan.
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MeSH Terms
Descriptor/Qualifier:
APACHE
Acute Disease
Complement C3
Complement C4
Female
Humans
Immunocompromised Host
Immunoglobulin G / blood
Immunoglobulin M / blood
Infection / complications,  epidemiology
Lymphocyte Count
Lymphocytes / blood
Male
Middle Aged
Pancreatitis / complications,  immunology*
Retrospective Studies
T-Lymphocytes
Chemical
Reg. No./Substance:
0/C3 protein, human; 0/Complement C3; 0/Complement C4; 0/Immunoglobulin G; 0/Immunoglobulin M

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