| Immunosuppressant regimen based on sirolimus decreases aortic stiffness in renal transplant recipients in comparison to cyclosporine. | |
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MedLine Citation:
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PMID: 21929645 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Whether or not a cyclosporine A (CsA)-free immunosuppressant regimen based on sirolimus (SRL) prevents aortic stiffening and improves central hemodynamics in renal recipients remains unknown. Forty-four patients (48 ± 2 years) enrolled in the CONCEPT trial were randomized at week 12 (W12) to continue CsA or switch to SRL, both associated with mycophenolate mofetil. Carotid systolic blood pressure (cSBP), pulse pressure (cPP), central pressure wave reflection (augmentation index, AIx) and carotid-to-femoral pulse-wave velocity (PWV: aortic stiffness) were blindly assessed at W12, W26 and W52 together with plasma endothelin-1 (ET-1), thiobarbituric acid-reactive substances (TBARS) and superoxide dismutase (SOD) and catalase erythrocyte activities. At W12, there was no difference between groups. At follow-up, PWV, cSBP, cPP and AIx were lower in the SRL group. The difference in PWV remained significant after adjustment for blood pressure and eGFR. In parallel, ET-1 decreased in the SRL group, while TBARS, SOD and catalase erythrocyte activities increased in both groups but to a lesser extent in the SRL group. Our results demonstrate that a CsA-free regimen based on SRL reduces aortic stiffness, plasma endothelin-1 and oxidative stress in renal recipients suggesting a protective effect on the arterial wall that may be translated into cardiovascular risk reduction. |
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Authors:
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R Joannidès; C Monteil; B H de Ligny; P F Westeel; M Iacob; E Thervet; S Barbier; J Bellien; Y Lebranchu; S G Seguin; C Thuillez; M Godin; I Etienne |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2011-09-19 |
Journal Detail:
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Title: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons Volume: 11 ISSN: 1600-6143 ISO Abbreviation: Am. J. Transplant. Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-10-27 Completed Date: 2012-02-28 Revised Date: 2012-04-17 |
Medline Journal Info:
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Nlm Unique ID: 100968638 Medline TA: Am J Transplant Country: United States |
Other Details:
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Languages: eng Pagination: 2414-22 Citation Subset: IM |
Copyright Information:
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©2011 The Authors Journal compilation © 2011 The American Society of Transplantation and the American Society of Transplant Surgeons. |
Affiliation:
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Department of Pharmacology, Rouen University Hospital, University of Rouen, Rouen, France. robinson.joannides@chu-rouen.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aorta Blood Pressure / drug effects Cyclosporine / adverse effects Endothelin-1 / blood Female Humans Immunosuppressive Agents / therapeutic use* Kidney Transplantation / methods* Male Middle Aged Mycophenolic Acid / analogs & derivatives, therapeutic use Sirolimus / therapeutic use* Vascular Stiffness / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Endothelin-1; 0/Immunosuppressive Agents; 128794-94-5/mycophenolate mofetil; 24280-93-1/Mycophenolic Acid; 53123-88-9/Sirolimus; 59865-13-3/Cyclosporine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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