| Immunostimulatory properties and enhanced TNF- alpha mediated cellular immunity for tumor therapy by C60(OH)20 nanoparticles. | |
| | |
MedLine Citation:
|
PMID: 19755733 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Publications concerning the mechanism of biological activity, especially the immunological mechanism of C(60)(OH)(20) nanoparticles, are relatively limited. However, the structure and characteristics of this carbon allotrope have been widely investigated. In this paper, we have demonstrated that water-soluble C(60)(OH)(20) nanoparticles have an efficient anti-tumor activity in vivo, and show specific immunomodulatory effects to the immune cells, such as T cells and macrophages, both in vivo and in vitro. For example, C(60)(OH)(20) nanoparticles can increase the production of T-helper cell type 1 (Th1) cytokines (IL-2, IFN- gamma and TNF-alpha), and decrease the production of Th2 cytokines (IL-4, IL-5 and IL-6) in serum samples. On the other hand, C(60)(OH)(20) nanoparticles show almost no adverse effect to the viability of immune cells in vitro but stimulate the immune cells to release more cytokines, in particular TNF- alpha, which plays a key role in the cellular immune process to help eliminate abnormal cells. TNF- alpha production increased almost three-fold in treated T lymphocytes and macrophages. Accordingly, we conclude that C(60)(OH)(20) nanoparticles have an efficient anti-tumor activity and this effect is associated with an increased CD(4)(+)/CD(8)(+) lymphocyte ratio and the enhancement of TNF- alpha production. The data suggest that C(60)(OH)(20) nanoparticles can improve the immune response to help to scavenge and kill tumor cells. |
| | |
Authors:
|
Ying Liu; Fang Jiao; Yang Qiu; Wei Li; Ying Qu; Chixia Tian; Yufeng Li; Ru Bai; Fang Lao; Yuliang Zhao; Zhifang Chai; Chunying Chen |
Related Documents
:
|
16493033 - Il-27 suppresses cd28-mediated [correction of medicated] il-2 production through suppre... 3878753 - Functional and quantitative changes of immune cells of ageing nzb mice treated with nan... 22098153 - Scutellaria litwinowii induces apoptosis through both extrinsic and intrinsic apoptotic... |
Publication Detail:
|
Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-09-16 |
Journal Detail:
|
Title: Nanotechnology Volume: 20 ISSN: 1361-6528 ISO Abbreviation: Nanotechnology Publication Date: 2009 Oct |
Date Detail:
|
Created Date: 2009-09-18 Completed Date: 2009-11-23 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101241272 Medline TA: Nanotechnology Country: England |
Other Details:
|
Languages: eng Pagination: 415102 Citation Subset: IM |
Affiliation:
|
CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, People's Republic of China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Carcinoma, Lewis Lung / drug therapy, immunology Cells, Cultured Flow Cytometry Fullerenes / pharmacology* Immunity, Cellular / drug effects* Interferon-gamma / metabolism Interleukin-2 / metabolism Interleukin-4 / metabolism Interleukin-5 / metabolism Lymphocytes / drug effects, metabolism Macrophages / drug effects, metabolism Mice Mice, Inbred C57BL Nanoparticles* Random Allocation Tumor Necrosis Factor-alpha / metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Fullerenes; 0/Interleukin-2; 0/Interleukin-5; 0/Tumor Necrosis Factor-alpha; 207137-56-2/Interleukin-4; 82115-62-6/Interferon-gamma |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Fluorescence signals of quantum dots influenced by spatially controlled array structures.
Next Document: Campylobacter enteritis in the Arabian Gulf.