| Immunostimulatory activity of the polysaccharides from Hyriopsis cumingii. | |
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MedLine Citation:
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PMID: 20804782 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The immunostimulatory activity of Hyriopsis cumingii polysaccharides (HCPS) was evaluated by using in vitro cell models and in vivo animal models. The results demonstrated that crude HCPS and its purified fractions (HCPS-1, HCPS-2 and HCPS-3) could promote the splenocyte proliferation, increase the activity of acid phosphatase in peritoneal macrophages and strengthen peritoneal macrophages to devour neutral red in vitro in a dose-dependent manner. Furthermore, HCPS-3 exhibited much stronger immunostimulatory activity in vitro than crude HCPS, HCPS-1 and HCPS-2, probably due to the higher sulfate content of HCPS-3. For assay in vivo, crude HCPS significantly increased the indices of spleen and thymus, the activity of lysozyme in serum and the swelling rate of earlap in delayed-type hypersensitivity in a dose-dependent manner. These results suggested that HCPS might be a potential natural immunomodulator. |
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Authors:
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Deliang Qiao; Jianguang Luo; Chunling Ke; Yi Sun; Hong Ye; Xiaoxiong Zeng |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-06 |
Journal Detail:
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Title: International journal of biological macromolecules Volume: 47 ISSN: 1879-0003 ISO Abbreviation: Int. J. Biol. Macromol. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-10-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7909578 Medline TA: Int J Biol Macromol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 676-80 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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College of Food Science and Technology, Nanjing Agricultural University, Weigang 1, Nanjing 210095, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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