| Immunostimulatory activity of cationic-lipid-nucleic-acid complexes against cancer. | |
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MedLine Citation:
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PMID: 11935307 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent studies have highlighted the immunostimulatory nature of nucleic acids and the enhancement of such immunostimulation when nucleic acids are complexed to cationic liposomes to form cationic-lipid-nucleic-acid-complexes or lipoplexes. While such immunostimulation may have deleterious consequences for nucleic acid delivery, especially in the field of gene therapy, it may be harnessed for efficacious usage against the various forms of cancer. |
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Authors:
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C R Dass |
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Publication Detail:
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Type: Journal Article; Review Date: 2002-02-23 |
Journal Detail:
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Title: Journal of cancer research and clinical oncology Volume: 128 ISSN: 0171-5216 ISO Abbreviation: J. Cancer Res. Clin. Oncol. Publication Date: 2002 Apr |
Date Detail:
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Created Date: 2002-04-05 Completed Date: 2002-05-29 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 7902060 Medline TA: J Cancer Res Clin Oncol Country: Germany |
Other Details:
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Languages: eng Pagination: 177-81 Citation Subset: IM |
Affiliation:
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Johnson & Johnson Research, 1 Central Avenue, Australian Technology Park, Eveleigh 1430, Australia. cdass@medau.jnj.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cations
/
chemistry,
immunology,
therapeutic use CpG Islands / genetics, immunology Gene Expression Regulation Gene Therapy Humans ISCOMs / administration & dosage, immunology*, therapeutic use Lipids / administration & dosage, immunology*, therapeutic use Liposomes Oligonucleotides / administration & dosage, immunology*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Cations; 0/ISCOMs; 0/Lipids; 0/Liposomes; 0/Oligonucleotides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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