Document Detail

Immunostimulatory activity of cationic-lipid-nucleic-acid complexes against cancer.
MedLine Citation:
PMID:  11935307     Owner:  NLM     Status:  MEDLINE    
Recent studies have highlighted the immunostimulatory nature of nucleic acids and the enhancement of such immunostimulation when nucleic acids are complexed to cationic liposomes to form cationic-lipid-nucleic-acid-complexes or lipoplexes. While such immunostimulation may have deleterious consequences for nucleic acid delivery, especially in the field of gene therapy, it may be harnessed for efficacious usage against the various forms of cancer.
C R Dass
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Publication Detail:
Type:  Journal Article; Review     Date:  2002-02-23
Journal Detail:
Title:  Journal of cancer research and clinical oncology     Volume:  128     ISSN:  0171-5216     ISO Abbreviation:  J. Cancer Res. Clin. Oncol.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-04-05     Completed Date:  2002-05-29     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7902060     Medline TA:  J Cancer Res Clin Oncol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  177-81     Citation Subset:  IM    
Johnson & Johnson Research, 1 Central Avenue, Australian Technology Park, Eveleigh 1430, Australia.
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MeSH Terms
Cations / chemistry,  immunology,  therapeutic use
CpG Islands / genetics,  immunology
Gene Expression Regulation
Gene Therapy
ISCOMs / administration & dosage,  immunology*,  therapeutic use
Lipids / administration & dosage,  immunology*,  therapeutic use
Oligonucleotides / administration & dosage,  immunology*,  therapeutic use
Reg. No./Substance:
0/Cations; 0/ISCOMs; 0/Lipids; 0/Liposomes; 0/Oligonucleotides

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