| Immunostimulatory activity of ConBr: a focus on splenocyte proliferation and proliferative cytokine secretion. | |
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MedLine Citation:
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PMID: 22009293 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Lectins constitute a class of glycoproteins, which are capable of selectively and reversibly binding to carbohydrates, distinguishing small structural differences in complex oligosaccharides. Studies have shown that the binding of lectins to cell-surface carbohydrates can lead to various effects such as cellular proliferation, histamine release and cytokine production. Canavalia brasiliensis lectin (ConBr) is a (D-mannose) D-glucose lectin. In this study, murine splenocytes were cultured to determine the effect of ConBr on cell proliferation, nitric oxide (NO) release and cytokine secretion. In addition, cellular viability assays were performed to evaluate any mitogenic activity induced by this lectin. ConBr significantly increased cell proliferation with minimal cell damage. This lectin was able to induce an increased production of cytokines such as IL-2, IL-6 and IFN-γ and a decreased production of IL- 10. The release of NO was also observed. The results of this study indicate that ConBr could potentially be used as an immunomodulator. |
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Authors:
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Flávio de Oliveira Silva; Priscila das Neves Santos; Cristiane Moutinho Lagos de Melo; Edson Holanda Teixeira; Benildo de Sousa Cavada; Valéria Alves Rêgo Pereira; Ana Lúcia Figueiredo Porto; João Batista Cajazeiras; Francisco Vassiliepe Sousa Arruda; Alysson Chaves Almeida |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-19 |
Journal Detail:
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Title: Cell and tissue research Volume: - ISSN: 1432-0878 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417625 Medline TA: Cell Tissue Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Departamento de Morfologia e Fisiologia Animal, Universidade Federal Rural de Pernambuco, Recife, Pernambuco, Brazil, foliveirasilva@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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