Document Detail


Immunostimulation to reduce recurrence after surgery for anal condyloma acuminata: a prospective randomized controlled trial.
MedLine Citation:
PMID:  19548899     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
AIM: Human papillomavirus is the most common cause of sexually transmitted disease. It is associated with immunosuppression and shows a marked tendency to recur. We investigated a natural immunostimulant aimed to reduce recurrence.
METHOD: A randomized controlled study was carried out including 261 patients allocated to surgical excision alone (control group; n = 122) and surgical excision plus postoperative immunostimulation for 30 days with a natural product (STET; study group; n = 139). Patients with HIV positivity were excluded. All patients gave fully informed consent.
RESULTS: The patients were followed for 6 months after surgery. Recurrence occurred in 7.2% (10/139) in the study group and in 27.1% (33/122) in the control group (P < 0.0001). There were no significant differences in the sex, sexual orientation, number of lesions, time to diagnosis and treatment or localization of lesions in the two groups.
CONCLUSIONS: Immunostimulation using a natural product significantly reduced the incidence of recurrence of anal condylomata in patients undergoing surgical excision.
Authors:
M Mistrangelo; S Cornaglia; M Pizzio; R Rimonda; G Gavello; I Dal Conte; A Mussa
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Publication Detail:
Type:  Journal Article     Date:  2009-06-22
Journal Detail:
Title:  Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland     Volume:  12     ISSN:  1463-1318     ISO Abbreviation:  Colorectal Dis     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883611     Medline TA:  Colorectal Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  799-803     Citation Subset:  IM    
Affiliation:
Oncological Surgical Department, University of Turin, 10126 Turin, Italy. mistrangelo@katamail.com
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