| Immunostimulation in the era of the metagenome. | |
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MedLine Citation:
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PMID: 21278764 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Microbes are increasingly being implicated in autoimmune disease. This calls for a re-evaluation of how these chronic inflammatory illnesses are routinely treated. The standard of care for autoimmune disease remains the use of medications that slow the immune response, while treatments aimed at eradicating microbes seek the exact opposite-stimulation of the innate immune response. Immunostimulation is complicated by a cascade of sequelae, including exacerbated inflammation, which occurs in response to microbial death. Over the past 8 years, we have collaborated with American and international clinical professionals to research a model-based treatment for inflammatory disease. This intervention, designed to stimulate the innate immune response, has required a reevaluation of disease progression and amelioration. Paramount is the inherent conflict between palliation and microbicidal efficacy. Increased microbicidal activity was experienced as immunopathology-a temporary worsening of symptoms. Further studies are needed, but they will require careful planning to manage this immunopathology.Cellular & Molecular Immunology advance online publication, 31 January 2011; doi:10.1038/cmi.2010.77. |
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Authors:
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Amy D Proal; Paul J Albert; Greg P Blaney; Inge A Lindseth; Chris Benediktsson; Trevor G Marshall |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-31 |
Journal Detail:
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Title: Cellular & molecular immunology Volume: - ISSN: 2042-0226 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101242872 Medline TA: Cell Mol Immunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Murdoch University, Perth, WA, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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