Document Detail

Immunostimulation in the era of the metagenome.
MedLine Citation:
PMID:  21278764     Owner:  NLM     Status:  MEDLINE    
Microbes are increasingly being implicated in autoimmune disease. This calls for a re-evaluation of how these chronic inflammatory illnesses are routinely treated. The standard of care for autoimmune disease remains the use of medications that slow the immune response, while treatments aimed at eradicating microbes seek the exact opposite-stimulation of the innate immune response. Immunostimulation is complicated by a cascade of sequelae, including exacerbated inflammation, which occurs in response to microbial death. Over the past 8 years, we have collaborated with American and international clinical professionals to research a model-based treatment for inflammatory disease. This intervention, designed to stimulate the innate immune response, has required a reevaluation of disease progression and amelioration. Paramount is the inherent conflict between palliation and microbicidal efficacy. Increased microbicidal activity was experienced as immunopathology-a temporary worsening of symptoms. Further studies are needed, but they will require careful planning to manage this immunopathology.
Amy D Proal; Paul J Albert; Greg P Blaney; Inge A Lindseth; Chris Benediktsson; Trevor G Marshall
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Publication Detail:
Type:  Journal Article; Review     Date:  2011-01-31
Journal Detail:
Title:  Cellular & molecular immunology     Volume:  8     ISSN:  2042-0226     ISO Abbreviation:  Cell. Mol. Immunol.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-03     Completed Date:  2011-09-06     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  101242872     Medline TA:  Cell Mol Immunol     Country:  China    
Other Details:
Languages:  eng     Pagination:  213-25     Citation Subset:  IM    
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MeSH Terms
Autoimmune Diseases / etiology,  immunology*,  physiopathology
Bacteria / immunology*,  pathogenicity
Disease Progression
Immunity, Innate
Infection / complications,  immunology*,  physiopathology
Metagenome / immunology*
Viruses / immunology*,  pathogenicity

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