| Immunostimulating effect of oral glutamine. | |
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MedLine Citation:
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PMID: 9724164 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glutamine represents the principal metabolic substrate for all rapidly proliferating cells. Since part of the glutamine efficacy could be related to immunoregulating properties, we assessed the effects of orally administered glutamine on serum interleukin-2 (IL-2) levels and intestinal T-cell populations in 48 athymic (nude) mice. Twenty-four mice received a standard diet enriched by glutamine (added to drinking water at a 4% concentration), while the other 24 served as the control group and received the same diet without glutamine. In glutamine-fed animals, we observed a marked increase in IL-2 concentrations after 10 days of treatment in comparison with control group and a modest but significant increase in intestinal T-cell counts. These results suggest that oral glutamine is able to exert local and systemic immunostimulating activity that could be of relevance in the prevention of gut integrity and immune defense loss associated, for example, with trauma, surgery, and starvation. |
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Authors:
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M R Gismondo; L Drago; M C Fassina; I Vaghi; R Abbiati; E Grossi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Digestive diseases and sciences Volume: 43 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 1998 Aug |
Date Detail:
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Created Date: 1998-09-16 Completed Date: 1998-09-16 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1752-4 Citation Subset: AIM; IM |
Affiliation:
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Clinical Microbiology Lab, L. Sacco Teaching Hospital, University of Milan, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adjuvants, Immunologic
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administration & dosage*,
pharmacology Administration, Oral Animals Female Glutamine / administration & dosage*, pharmacology Interleukin-2 / blood* Intestinal Mucosa / cytology, immunology* Mice Mice, Nude T-Lymphocyte Subsets T-Lymphocytes / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Immunologic; 0/Interleukin-2; 56-85-9/Glutamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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