| Immunostaining in Mohs micrographic surgery: a review. | |
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MedLine Citation:
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PMID: 20100275 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: With the advent of incorporating the immunoperoxidase staining technique into the processing of frozen tissue, the use of Mohs micrographic surgery (MMS) has been expanded to include several high-risk tumors such as lentigo maligna, malignant melanoma, and dermatofibrosarcoma protuberans. OBJECTIVES: To thoroughly review the English medical literature pertaining to the use of immunohistochemical staining techniques on frozen sections during MMS and to summarize the basic relevant outcomes from the different relevant studies. MATERIALS AND METHODS: Medline search was conducted, with the following words used in the search criteria: "Mohs surgery,""staining,""immunostaining," and "immunoperoxidase." RESULTS Generally, all immunostains showed advantage over the traditional hematoxylin and eosin approach. Studies of MART-1 in melanoma chemosurgery indicated that it is typically crisp and has less background staining than MEL-5 and better staining consistency than HMB-45. In cases of desmoplastic melanomas, S100 is the stain of choice. CONCLUSION: Immunostaining offers an advantage in MMS. Large, randomized, prospective studies comparing the different immunostains are still lacking in the literature. The authors have indicated no significant interest with commercial supporters. |
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Authors:
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Abdel Kader El Tal; Ayad E Abrou; Mark A Stiff; David A Mehregan |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-01-19 |
Journal Detail:
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Title: Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] Volume: 36 ISSN: 1524-4725 ISO Abbreviation: Dermatol Surg Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-04-20 Completed Date: 2010-05-11 Revised Date: 2011-05-25 |
Medline Journal Info:
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Nlm Unique ID: 9504371 Medline TA: Dermatol Surg Country: United States |
Other Details:
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Languages: eng Pagination: 275-90 Citation Subset: IM |
Affiliation:
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Dermatology Department, Wayne State University, Dearborn, Michigan, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, Neoplasm
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diagnostic use Dermatofibrosarcoma / diagnosis Frozen Sections Humans Hutchinson's Melanotic Freckle / surgery Immunoenzyme Techniques / methods* Immunohistochemistry / methods* MART-1 Antigen Melanoma / immunology, surgery Melanoma-Specific Antigens Mohs Surgery* Neoplasm Proteins / diagnostic use S100 Proteins / diagnostic use Sensitivity and Specificity Skin Neoplasms / immunology, surgery |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Neoplasm; 0/MART-1 Antigen; 0/MLANA protein, human; 0/Melanoma-Specific Antigens; 0/Neoplasm Proteins; 0/S100 Proteins |
| Comments/Corrections | |
Comment In:
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Dermatol Surg. 2011 Apr;37(4):550
[PMID:
21481072
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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