| Immunoscintigraphy with anti-225.28S for ocular melanoma--a comparison with histology and immunohistochemistry. | |
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MedLine Citation:
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PMID: 9090646 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: The purpose of this prospective study was to evaluate the value of immunoscintigraphy (ISG) with anti-225.28S in clinically suspected ocular melanoma. METHODS: For this purpose standardized ISG was performed in 36 patients using both planar acquisition and emission computed tomography (ECT). Ocular melanoma was present in 31 patients. In 21 patients therapy was enucleation of the eye. These specimens were evaluated by histology and immunohistochemistry in 11 of 21 patients. RESULTS: Regarding the clinical diagnosis, ISG was positive only in 15 of 31 patients with ocular melanoma, regarding histology in 11 of 21 and regarding immunohistochemistry in 5 of 6 patients with a positive immunoreaction 5 patients showed no immunoreactivity, their ISG was negative. CONCLUSION: Thus a good correlation between ISG and immunohistochemistry was observed. However ISG using the cutaneous melanoma antibody 225.28S cannot be recommended for the diagnostic work-up of an ocular melanoma considering the poor immunoreactivity. |
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Authors:
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P Bräutigam; K U Loeffler; T Krause; S Högerle; J Simon; E Moser |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nuklearmedizin. Nuclear medicine Volume: 36 ISSN: 0029-5566 ISO Abbreviation: Nuklearmedizin Publication Date: 1997 Mar |
Date Detail:
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Created Date: 1997-05-15 Completed Date: 1997-05-15 Revised Date: 2007-01-12 |
Medline Journal Info:
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Nlm Unique ID: 7609387 Medline TA: Nuklearmedizin Country: GERMANY |
Other Details:
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Languages: eng Pagination: 42-6 Citation Subset: IM |
Affiliation:
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Abteilung Nuklearmedizin, Radiologische Universitätsklinik Freiburg, Deutschland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Antibodies, Monoclonal Biopsy Eye Enucleation Eye Neoplasms / pathology*, radionuclide imaging*, surgery False Positive Reactions Female Humans Immunohistochemistry Lymphatic Metastasis Male Melanoma / pathology*, radionuclide imaging*, surgery Middle Aged Necrosis Prospective Studies Radioimmunodetection* Technetium / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 7440-26-8/Technetium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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