| Immunoscintigraphy performed with In-111-labeled CYT-103 in the management of colorectal cancer: comparison with CT. | |
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MedLine Citation:
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PMID: 1523304 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Immunoscintigraphy performed after intravenous administration of indium-111-labeled CYT-103, an immunoconjugate of monoclonal antibody B72.3, was evaluated in patients with suspected primary or recurrent colorectal cancer at 25 centers in the United States. Gamma camera imaging, computed tomography (CT), and confirmatory surgical exploration were completed in 169 of 227 patients who received single infusions of In-111 CYT-103. Eight patients (3.5%) had reversible, nonserious adverse reactions, and 39% developed antimurine antibodies. Surgery revealed that 155 of 169 patients had colorectal carcinoma. In these 155 patients, immunoscintigraphy and CT demonstrated similar sensitivity (69% and 68%, respectively) and specificity (77%). However, immunoscintigraphy had greater sensitivity in detection of pelvic tumors (74% vs 57%, P = .035) and extrahepatic abdominal tumors (66% vs 34%, P less than .001); CT enabled detection of a greater proportion of liver metastases (84% vs 41%, P less than .001). These results indicate that In-111 CYT-103 can be administered safely and that immunoscintigraphy performed with this agent frequently enables identification of extrahepatic abdominal sites of disease not visualized with CT. |
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Authors:
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B D Collier; H Abdel-Nabi; R J Doerr; S J Harwood; J Olsen; E H Kaplan; G G Winzelberg; S J Grossman; D N Krag; E P Mitchell |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Radiology Volume: 185 ISSN: 0033-8419 ISO Abbreviation: Radiology Publication Date: 1992 Oct |
Date Detail:
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Created Date: 1992-10-15 Completed Date: 1992-10-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 179-86 Citation Subset: AIM; IM |
Affiliation:
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Department of Nuclear Medicine, Medical College of Wisconsin, Milwaukee 53226. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antibodies, Monoclonal / diagnostic use* Antigens, Neoplasm / blood Colorectal Neoplasms / blood, radionuclide imaging* Female Glycoproteins / blood Humans Indium Radioisotopes / diagnostic use* Male Middle Aged Oligopeptides / diagnostic use* Pentetic Acid / analogs & derivatives*, diagnostic use Radioimmunodetection* Tomography, X-Ray Computed* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Antigens, Neoplasm; 0/Glycoproteins; 0/Indium 111In-satumomab pendetide; 0/Indium Radioisotopes; 0/Oligopeptides; 0/tumor-associated antigen 72; 67-43-6/Pentetic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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