Document Detail


Immunoregulatory studies in patients with IgA nephropathy.
MedLine Citation:
PMID:  3260958     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Numerous studies have evaluated T cell subsets and in vitro IgA synthesis in patients with IgA nephropathy. These reports have resulted in the hypothesis that defective regulation of IgA synthesis is important in the pathogenesis of IgA nephropathy. Baseline immunologic measurements were performed in a clinically well characterized group of 19 pediatric and 13 adult (greater than or equal to 18 years) patients with no macrohematuria or intercurrent infection at the time of study. Mean percentages of OKT3 and OKT4 subsets were significantly decreased for the patients as compared to healthy adult controls. Mean T4:T8 ratios were similar for control and patient groups although 7 patients had T4:T8 ratios greater than 2 SD above the control mean. Unstimulated and pokeweed mitogen stimulated in vitro IgA synthesis was similar for patients and controls. During six episodes of macrohematuria in five patients no significant changes occurred for T cell subset percentages, while mean T4:T8 ratios decreased from baseline. Mean serum concentration of IgA increased during these episodes, although in vitro IgA synthesis remained normal. Our data fail to demonstrate a consistent immunoregulatory abnormality for patients with IgA nephropathy.
Authors:
R J Wyatt; W R Valenski; F B Stapleton; S Roy; T D Woolridge; R L Trouy; H G Herrod
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of clinical & laboratory immunology     Volume:  25     ISSN:  0141-2760     ISO Abbreviation:  J Clin Lab Immunol     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-09-02     Completed Date:  1988-09-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7808987     Medline TA:  J Clin Lab Immunol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  109-14     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University of Tennessee, Memphis.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Child
Child, Preschool
Female
Glomerulonephritis, IGA / immunology*
Humans
Immunoglobulin A / analysis
Male
Middle Aged
T-Lymphocytes / classification
Grant Support
ID/Acronym/Agency:
RR 00211/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Immunoglobulin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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