Document Detail


Immunoregulatory properties of CD44+ cancer stem-like cells in squamous cell carcinoma of the head and neck.
MedLine Citation:
PMID:  20848440     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: CD44 was found as a surface marker in cancer stem cell (CSC) of squamous cell carcinoma of the head and neck (SCCHN); however, the immunologic properties of such CSCs have not yet been elucidated.
METHODS: The immunologic properties of CD44+ cancer stem-like cells were compared with those of CD44- cells using flow cytometry and enzyme-linked immunosorbent assay.
RESULTS: CD44+ cells exhibited weak HLA-A2 and class II expression. Interestingly, downregulation of transporter antigen processing (TAP)2 was found in CD44+ cells. The CD44+ cell population produced significantly higher levels of interleukin (IL)-8, granulocyte colony-stimulating factor (G-CSF), and transforming growth factor (TGF)-β than the CD44- cell population. Moreover, CD44+ cells have been shown to not only more strongly inhibit T-cell proliferation, but also to more efficiently inhibit regulatory T cells (Treg cells) and myeloid-derived suppressor cells (MDSC) as compared with CD44- cells. Additionally, CD44+ cells suppressed Th1 responses and enhanced regulatory T cell responses.
CONCLUSION: CSCs might have higher malignant potential with numerous escape strategies from immune attack.
Authors:
Kazuaki Chikamatsu; Goro Takahashi; Koichi Sakakura; Soldano Ferrone; Keisuke Masuyama
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Head & neck     Volume:  33     ISSN:  1097-0347     ISO Abbreviation:  Head Neck     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-17     Completed Date:  2011-05-27     Revised Date:  2012-09-27    
Medline Journal Info:
Nlm Unique ID:  8902541     Medline TA:  Head Neck     Country:  United States    
Other Details:
Languages:  eng     Pagination:  208-15     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Wiley Periodicals, Inc.
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, University of Yamanashi, Faculty of Medicine, Chuo, Yamanashi, 409-3898, Japan. chikamatsu@yamanashi.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Antigens, CD44 / immunology*
Biological Markers / metabolism
Carcinoma / immunology,  pathology
Carcinoma, Squamous Cell
Enzyme-Linked Immunosorbent Assay
Flow Cytometry
HLA-A2 Antigen / immunology
Head and Neck Neoplasms / immunology,  pathology
Humans
Neoplasms, Squamous Cell / immunology,  pathology
Neoplastic Stem Cells / immunology*
Grant Support
ID/Acronym/Agency:
P01 CA109688/CA/NCI NIH HHS; R01 CA110249/CA/NCI NIH HHS; R01 CA138188/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, CD44; 0/Biological Markers; 0/CD44 protein, human; 0/HLA-A2 Antigen
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