Document Detail

Immunoregulatory molecules are master regulators of inflammation during the immune response.
MedLine Citation:
PMID:  22819828     Owner:  NLM     Status:  MEDLINE    
The balance between pro- and anti-inflammatory signalling is critical to maintain the immune homeostasis under physiological conditions as well as for the control of inflammation in different pathological settings. Recent progress in the signalling pathways that control this balance has led to the development of novel therapeutic agents for diseases characterized by alterations in the activation/suppression of the immune response. Different molecules have a key role in the regulation of the immune system, including the receptors PD-1 (Programmed cell Death 1), CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) and galectins; or the intracellular enzyme IDO (indoleamine 2,3-dioxygenase). In addition, other molecules as CD69, AhR (Aryl hydrocarbon Receptor), and GADD45 (Growth Arrest and DNA Damage-inducible 45) family members, have emerged as potential targets for the regulation of the activation/suppression balance of immune cells. This review offers a perspective on well-characterized as well as emergent negative immune regulatory molecules in the context of autoimmune inflammatory diseases.
Hortensia de la Fuente; Danay Cibrián; Francisco Sánchez-Madrid
Related Documents :
22630828 - Response to: "meanderings into the regulation of effector class by the immune system: d...
22319668 - The emerging role of matrix metalloproteases of the adam family in male germ cell apopt...
16729718 - The modulatory role of melatonin on immune responsiveness.
22449938 - Iron levels in polarized macrophages: regulation of immunity and autoimmunity.
1573548 - Host responses in periodontal diseases: current concepts.
15994108 - In vivo efficiency of targeted norfloxacin against persistent, isoniazid-insensitive, m...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-07-20
Journal Detail:
Title:  FEBS letters     Volume:  586     ISSN:  1873-3468     ISO Abbreviation:  FEBS Lett.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-13     Completed Date:  2012-10-23     Revised Date:  2014-09-04    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  2897-905     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adjuvants, Immunologic / pharmacology*
Inflammation / immunology*
Signal Transduction
Grant Support
294340//European Research Council
Reg. No./Substance:
0/Adjuvants, Immunologic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  SARA is dispensable for functional TGF-? signaling.
Next Document:  N-terminal tyrosine phosphorylation of caveolin-2 negates anti-proliferative effect of transforming ...