| Immunoregulatory factors contributing to fetal allograft survival. | |
| | |
MedLine Citation:
|
PMID: 1814410 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A mammalian fetus expresses a variety of antigens potentially unknown to the immunologically competent mother. Presented here are the results of investigations of maternal immune reactivity to paternally derived antigens of fetoplacental unit, detected at various levels: 1) spleen and distant lymphatic organs, 2) regional lymph nodes draining uterus, and 3) materno-fetal interface. The results suggest that the mother's immune system reacts differently in semiallogeneic pregnancies than in syngeneic ones. The type of the systemic immune response depends on the stage of pregnancy. Increased percentage of CD8+ cells and decreased CD4+/CD8+ cell ratio was found in distant and regional lymphatic organs during pregnancy. The paternal class I MHC antigens expressed on the trophoblast cells are nonpolymorphic molecules which can have a role in immunotrophism of the placenta and in fetal allograft protection. |
| | |
Authors:
|
D Rukavina; M Kapović; A Radojcić |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The International journal of developmental biology Volume: 35 ISSN: 0214-6282 ISO Abbreviation: Int. J. Dev. Biol. Publication Date: 1991 Sep |
Date Detail:
|
Created Date: 1992-06-25 Completed Date: 1992-06-25 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8917470 Medline TA: Int J Dev Biol Country: SPAIN |
Other Details:
|
Languages: eng Pagination: 275-8 Citation Subset: IM; X |
Affiliation:
|
Department of Physiology and Immunology, University of Rijeka, Medical Faculty, Republic of Croatia, Yugoslavia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals CD4-CD8 Ratio Decidua / immunology Female Fetus / immunology* Histocompatibility Antigens Class I / analysis Lymph Nodes / immunology* Pregnancy / immunology* Rats Rats, Inbred Strains Spleen / immunology* Trophoblasts / immunology |
| Chemical | |
Reg. No./Substance:
|
0/Histocompatibility Antigens Class I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Stereological analysis of alpha and beta zones of syncytiotrophoblast in human term placenta.
Next Document: Human brain gangliosides in development, aging and disease.