| Immunoregulatory disorders associated with hereditary angioedema. I. Clinical manifestations of autoimmune disease. | |
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MedLine Citation:
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PMID: 3084606 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Occasional reports have appeared linking hereditary angioedema (HAE) with autoimmune diseases. We have systematically evaluated 157 patients for manifestations of autoimmunity. Nineteen of these patients (12%) had clinical immunoregulatory diseases including glomerulonephritis (five patients), Sjögren's syndrome (three), inflammatory bowel disease (three), thyroiditis (two), systemic lupus erythematosus (one), drug-induced lupus (one), rheumatoid arthritis (one), juvenile rheumatoid arthritis with IgA deficiency (one), incipient pernicious anemia (one), and sicca syndrome (one). All eight patients with HAE who developed an autoimmune disease with a known human histocompatibility antigen association developed a disease associated with their histocompatibility antigen haplotype (p = 0.014). Although only four patients developed Sjögren's syndrome or sicca syndrome, an additional nine manifested part of the sicca complex. We also found patients with HAE with features suggestive of an immune-based abnormality. These features included idiopathic pancreatitis (three patients), Raynaud's disease (two), partial lipodystrophy (one), chronic chorioretinitis (one), and alopecia universalis (one). |
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Authors:
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C M Brickman; G C Tsokos; J E Balow; T J Lawley; M Santaella; C H Hammer; M M Frank |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of allergy and clinical immunology Volume: 77 ISSN: 0091-6749 ISO Abbreviation: J. Allergy Clin. Immunol. Publication Date: 1986 May |
Date Detail:
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Created Date: 1986-06-16 Completed Date: 1986-06-16 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1275002 Medline TA: J Allergy Clin Immunol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 749-57 Citation Subset: AIM; IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Angioedema / genetics, immunology* Autoimmune Diseases / complications, immunology B-Lymphocytes Female Genes, MHC Class II Humans Kidney Diseases / immunology Lupus Erythematosus, Systemic / immunology Male Middle Aged Thyroiditis / immunology |
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