| Immunoreactive thymosin alpha 1 is associated with murine T-cell lymphomas. | |
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MedLine Citation:
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PMID: 6096635 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Growth of murine spontaneous and transplanted AKR T-cell lymphomas results in marked elevations of serum immunoreactive thymosin alpha 1. Thymosin alpha 1 is one of the peptide hormones believed to be secreted primarily by the thymic epithelium. This elevation, however, is not mediated by the thymus but rather, seems to be directly associated with the tumor cells. Growth of a B-cell lymphoma does not generate elevated immunoreactive thymosin alpha 1 in the serum, thus, a thymosin alpha 1-like peptide is selectively associated with these T-cell lymphomas. The possible relationship between expression of T-leukemia viruses and alpha 1 expression is discussed. |
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Authors:
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M M Zatz; J E McClure; A L Goldstein |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Leukemia research Volume: 8 ISSN: 0145-2126 ISO Abbreviation: Leuk. Res. Publication Date: 1984 |
Date Detail:
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Created Date: 1985-02-11 Completed Date: 1985-02-11 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7706787 Medline TA: Leuk Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1003-10 Citation Subset: IM; X |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acquired Immunodeficiency Syndrome
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blood Age Factors Animals Deltaretrovirus Lymphoma / blood* Male Mice Mice, Inbred AKR T-Lymphocytes* Thymosin / analogs & derivatives*, blood, immunology Thymus Gland / physiology |
| Grant Support | |
ID/Acronym/Agency:
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CA 24974/CA/NCI NIH HHS; CA 29943/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/thymalfasin; 61512-21-8/Thymosin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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