| Immunoreactive thromboxane synthase is measurable in ovine fetal hypothalamus as early as 86 days' gestation. | |
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MedLine Citation:
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PMID: 9380799 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thromboxane A2 (TxA2) augments hypothalamus-pituitary-adrenal axis activity in both fetal and adult animals. We have proposed that TxA2 acts as a neuromodulator within the brain to stimulate the release of corticotropin releasing hormone (CRH) or arginine vasopressin (AVP) into the hypophyseal-portal blood. We performed the present experiments to identify immunoreactive thromboxane synthase (TxS) within fetal brain regions and to quantify developmental changes in the TxS immunoreactivity measurable within those regions. We found that immunoreactive TxS was present in fetal hypothalamus, pituitary, brainstem, and lung. In fetal hypothalamus, we found immunoreactive TxS in three identifiable molecular weights, approximately 65, 42, and 35 kD. In fetal pituitary and lung, we found the 65 and 35 kD forms, and in the brainstem we found only the 35 kD form. In fetal pituitary, there was a clear ontogenetic change in TxS immunoreactivity. The 42 kD TxS immunoreactivity was not present in the youngest fetal sheep studied (86-90 days' gestation), but was expressed in the other age groups (125-128, 135-139, 141-term, and postnatal ages). The other molecular weight forms appeared to increase in the older fetuses, but the changes were not significant. In the hypothalamus, all three forms of TxS were measurable at all ages, and there was no significant change in relative abundance. We conclude that immunoreactive TxS is present in the fetal brain throughout the last half of fetal gestation, but that the significance of multiple molecular weight forms is not clear. |
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Authors:
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C E Wood; S Purinton; T A Cudd |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Prostaglandins Volume: 54 ISSN: 0090-6980 ISO Abbreviation: Prostaglandins Publication Date: 1997 Aug |
Date Detail:
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Created Date: 1997-11-07 Completed Date: 1997-11-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0320271 Medline TA: Prostaglandins Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 569-79 Citation Subset: IM |
Affiliation:
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Department of Physiology, University of Florida College of Medicine, Gainesville 32610-0274, USA. CWOOD@phys.med.ufl.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Stem / embryology, enzymology Gestational Age* Hypothalamus / embryology*, enzymology* Lung / embryology, enzymology Molecular Weight Pituitary Gland / embryology, enzymology Sheep / embryology* Thromboxane-A Synthase / analysis*, chemistry |
| Chemical | |
Reg. No./Substance:
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EC 5.3.99.5/Thromboxane-A Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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