| Immunoreactive substance P release from skin nerves in the rat by noxious thermal stimulation. | |
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MedLine Citation:
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PMID: 2419806 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have examined by radioimmunoassay the substance P (IR-SP) content of superfusate obtained from skin blisters in the anesthetized rat. The blisters were produced on the footpad using a vacuum pump, and the blister base was superfused with tyrode solution. Continuous release of IR-SP was approximately 100 pg/h from the innervated footpad but was considerably reduced when the footpad had been surgically denervated 10-14 days previously. The IR-SP content was markedly increased in the innervated footpad following a local noxious heat stimulus of 50 degrees C applied for 30 s at 5-min intervals for 1 h. The results support the proposal that SP is a mediator of neurogenic inflammation induced by noxious skin heating. |
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Authors:
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R D Helme; G M Koschorke; M Zimmermann |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroscience letters Volume: 63 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 1986 Jan |
Date Detail:
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Created Date: 1986-04-02 Completed Date: 1986-04-02 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 295-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blister / metabolism Blood Proteins / analysis Hot Temperature Male Nervous System / metabolism Nociceptors / physiology Physical Stimulation Radioimmunoassay Rats Rats, Inbred Strains Skin / innervation* Substance P / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Blood Proteins; 33507-63-0/Substance P |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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