Document Detail

Immunoreactive substance P release from skin nerves in the rat by noxious thermal stimulation.
MedLine Citation:
PMID:  2419806     Owner:  NLM     Status:  MEDLINE    
We have examined by radioimmunoassay the substance P (IR-SP) content of superfusate obtained from skin blisters in the anesthetized rat. The blisters were produced on the footpad using a vacuum pump, and the blister base was superfused with tyrode solution. Continuous release of IR-SP was approximately 100 pg/h from the innervated footpad but was considerably reduced when the footpad had been surgically denervated 10-14 days previously. The IR-SP content was markedly increased in the innervated footpad following a local noxious heat stimulus of 50 degrees C applied for 30 s at 5-min intervals for 1 h. The results support the proposal that SP is a mediator of neurogenic inflammation induced by noxious skin heating.
R D Helme; G M Koschorke; M Zimmermann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience letters     Volume:  63     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1986 Jan 
Date Detail:
Created Date:  1986-04-02     Completed Date:  1986-04-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  295-9     Citation Subset:  IM    
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MeSH Terms
Blister / metabolism
Blood Proteins / analysis
Hot Temperature
Nervous System / metabolism
Nociceptors / physiology
Physical Stimulation
Rats, Inbred Strains
Skin / innervation*
Substance P / metabolism*
Reg. No./Substance:
0/Blood Proteins; 33507-63-0/Substance P

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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