Document Detail


Immunoreactive leukotriene C4 levels in CSF of MS patients.
MedLine Citation:
PMID:  1621501     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Using a sensitive and specific radioimmunoassay levels of leukotriene (LT)C4-like material were estimated in lumbar cerebrospinal fluid (CSF) samples from patients with multiple sclerosis (MS) in comparison to control patients with or without inflammatory processes in the central nervous system (CNS). Levels of LTC4-like material were significantly elevated (p less than 0.01) in CSF from patients with inflammatory diseases such as meningitis, polyradiculitis or meningoencephalitis (57 +/- 53 pg/ml, n = 16) as compared to those from control patients without inflammatory or immunological CNS diseases (21 +/- 16 pg/ml, n = 42). By contrast, LTC4-like material was 16 +/- 7 pg/ml in first manifestations of MS (n = 7). 21 +/- 16 pg/ml in remitting-relapsing MS (n = 15) and 10 +/- 6 pg/ml in chronic progressive MS (n = 8). These results argue against a significant pathophysiological role of cysteinyl-LT in MS.
Authors:
M Haupts; K Smektala; T Finkbeiner; T Simmet; W Gehlen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  85     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-08-06     Completed Date:  1992-08-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  365-7     Citation Subset:  IM    
Affiliation:
Department of Neurology, Knappschaftskrankenhaus, Ruhr-University Bochum, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood-Brain Barrier
Eicosanoids / cerebrospinal fluid
Female
Humans
Immune System Diseases / cerebrospinal fluid,  physiopathology
Immunoglobulin G / cerebrospinal fluid,  immunology
Male
Multiple Sclerosis / cerebrospinal fluid,  immunology*,  physiopathology
Radioimmunoassay
SRS-A / biosynthesis,  immunology,  pharmacokinetics*
Chemical
Reg. No./Substance:
0/Eicosanoids; 0/Immunoglobulin G; 0/SRS-A

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