Document Detail

Immunoreactive erythropoietin concentration and haemoglobin type in the perinatal period in sheep of various haemoglobin genotypes.
MedLine Citation:
PMID:  2129243     Owner:  NLM     Status:  MEDLINE    
This study examines the hypotheses that (i) erythropoietin (the hormone responsible for red blood cell production) is higher in the fetus (at low PO2) than in the neonate (at high PO2); and (ii) that the level of erythropoietin in the neonate is influenced by the presence of high oxygen affinity haemoglobin. Haematocrit (PCV), PO2 and plasma immunoreactive erythropoietin were measured in 4 chronically cannulated fetal sheep (120 days to birth, n = 22) and in 7 neonatal lambs until 233 days post-conception (75-85 days after birth, n = 83). The percentage of globin chains (alpha, gamma, beta A, beta B, beta C) was quantitated by gel electrophoresis. Plasma erythropoietin values, in 4 fetuses were 9.8 +/- 1.3 mU/ml at 120-132 days of gestation, declined significantly (P less than 0.01) to 5.2 +/- 0.4 at 133 days until birth, then increased significantly (P less than 0.001) to 24.2 +/- 5.5(5), 26.3 +/- 7.3 (6), and 24.8 +/- 8.5 (6), respectively in weeks 1, 2 and 3 of postnatal life. By weeks 5-8 the erythropoietin was 13 +/- 0.6 (4) mU/ml. PO2 was 17.4 +/- 0.9 mmHg before birth and 88.0 +/- 10.7 in the first week after birth. PCV was constant until three weeks after birth and then declined. Fetal haemoglobin had virtually disappeared from the circulation by 166 days (3 weeks after birth); in the 4 heterozygotes (beta A beta B) beta C was expressed transiently, with a maximum value of 4%, whilst in the homozygote lamb (beta A beta A) the maximum beta C was 12%.(ABSTRACT TRUNCATED AT 250 WORDS)
E M Wintour; G Clemons; A Butkus; A Horvath; K Moritz; M K Towstoless
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of developmental physiology     Volume:  14     ISSN:  0141-9846     ISO Abbreviation:  J. Dev. Physiol.     Publication Date:  1990 Nov 
Date Detail:
Created Date:  1991-08-29     Completed Date:  1991-08-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7910737     Medline TA:  J Dev Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  259-65     Citation Subset:  IM    
Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Australia.
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MeSH Terms
Aging / physiology*
Analysis of Variance
Animals, Newborn
Blood Chemical Analysis
Blood Gas Analysis
Carbon Dioxide / blood
Erythropoietin / blood*
Fetal Blood / chemistry*
Hemoglobins / analysis,  genetics*
Hydrogen-Ion Concentration
Oxygen / blood
Grant Support
Reg. No./Substance:
0/Hemoglobins; 11096-26-7/Erythropoietin; 124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

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