| Immunoreactive and Bioactive Growth Hormone Responses to Resistance Exercise in Men Who Are Lean or Obese. | |
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MedLine Citation:
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PMID: 21636569 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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It has been suggested that obese individuals have a blunted growth hormone (GH) response to spontaneous and stimulated GH secretion. The present study was designed to examine the effects of a high volume, whole body resistance acute exercise protocol on immunoreactive GH (iGH), bioactive GH (bGH) and growth hormone binding protein (GHBP) in sedentary lean and obese men. Nine obese (mean ± SD age: 20.8±2.1 height: 177.0±4.1 (cm) body mass: 108.7±15.9 (kg) body fat: 37.6± 5.29 (%) ) and nine lean (mean ± SD age: 20.1±2.1 height: 177.8±8.7 (cm) body mass: 71.7±5.8 (kg) body fat: 14.7±3.54 (%)) men completed an acute resistance exercise protocol (6 exercises, 3 sets of 10 repetitions at 85-95% 10RM with 120s and 90s rest periods) and blood samples were collected pre, mid, immediately post exercise and during recovery (+50, +70 and +110). Unlike prior studies which examined acute responses to cardiovascular exercise protocols groups did not differ in iGH response to the exercise stimulus. However, bGH concentrations overall were significantly lower in the obese participants than in the lean participants (p<.001). Additionally, obese individuals had significantly higher GHBP concentrations (p<.001). Results suggest both obese and lean sedentary men performing a high volume, whole body acute resistance exercise protocol demonstrate similar increases in iGH. Blunted bGH and elevated GHBP concentrations are indicative of altered GH activity associated with obesity. Prior research findings of blunted iGH response may be attributable to resistance exercise protocols not equated on relative intensity or volume. These results underscore the complexity of pituitary biology and its related mechanisms and may have implications for exercise prescription in the treatment of obesity. |
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Authors:
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Gwendolyn A Thomas; William J Kraemer; Mary J Kennett; Brett A Comstock; Carl M Maresh; Craig R Denegar; Jeff S Volek; Wesley C Hymer |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-2 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Yale University. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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