| The Immunophysiology and Apoptosis of Biliary Epithelial Cells: Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis. | |
| | |
MedLine Citation:
|
PMID: 22689287 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Biliary epithelial cells (BECs) provide the first line of defense against lumenal microbes in the biliary system. BECs express a variety of pathogen recognition receptors and can activate several intracellular signaling cascades to initiate antimicrobial defenses, including production of several anti-microbial peptides, cytokines, chemokines, and adhesion molecules. BECs also secrete immunoglobulin A and interact with other cells through expression and release of adhesion molecules and immune mediators. Recently, several reports suggest a correlation between apoptosis and autoimmunity through ineffective clearance of self-antigens. Primary biliary cirrhosis (PBC) is a slowly progressive, autoimmune cholestatic liver disease characterized by highly specific antimitochondrial antibodies (AMAs) and the specific immune-mediated destruction of BECs. We have demonstrated that the AMA self-antigen, namely the E2 subunit of the pyruvate dehydrogenase complex, is detectable in its antigenically reactive form within apoptotic blebs from human intrahepatic biliary epithelial cells and activates innate immune responses. Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by inflammation and the presence of concentric fibrosis of intrahepatic and/or extrahepatic bile ducts, eventually leading to cirrhosis. However, apoptosis does not appear to play a central role in PSC. Despite both diseases involving immune-mediated injury to bile ducts, apoptosis occurs more commonly overall in PBC where it likely plays a unique role. |
| | |
Authors:
|
Kazuhito Kawata; Yoshimasa Kobayashi; M Eric Gershwin; Christopher L Bowlus |
Related Documents
:
|
22579587 - Prolongation of carrageenan-induced inflammation in human colonic epithelial cells by a... 10535687 - Do local immune-neuroendocrine disturbances initiate diabetes? 2056927 - The immune system is a key factor in the etiology of psychosocial disease. 22644107 - Intravenous immunoglobulin preparation attenuates lps-induced production of pro-inflamm... 22003197 - The nlrp3 inflammasome contributes to brain injury in pneumococcal meningitis and is ac... 22200667 - Intrarectal administration of milk fat globule epidermal growth factor-8 protein amelio... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-6-12 |
Journal Detail:
|
Title: Clinical reviews in allergy & immunology Volume: - ISSN: 1559-0267 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
|
Created Date: 2012-6-12 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9504368 Medline TA: Clin Rev Allergy Immunol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, 451 E. Health Sciences Drive, Suite 6510, Davis, CA, 95616, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Corrosion resistance, chemistry, and mechanical aspects of Nitinol surfaces formed in hydrogen perox...
Next Document: Clinical assessment of dynamic coefficient of friction effects in shoe-sole trituration of patients ...