Document Detail


Immunophenotypic profile of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia.
MedLine Citation:
PMID:  16191510     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We retrospectively reviewed the immunophenotypic profile of 75 cases of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (LPL/WM) analyzed by flow cytometry. All patients had monoclonal IgM (median, 2,100 mg/dL [21 g/L]) in serum and were considered clinically to have WM. The neoplastic cells, in all cases, expressed monoclonal immunoglobulin light chain (k, 55; l, 20) and CD19, and every case assessed was positive for CD20 (n=68) and CD52 (n=60). The results for other antigens assessed in decreasing frequency of positivity were as follows: surface IgM (26/28 [93%]), CD79b (11/13 [85%]), CD11c (13/16 [81%]), CD25 (5/7 [71%]), CD23 (17/28 [61%]), CD38 (24/50 [48%]), FMC7 (11/29 [38%]), CD22 (4/12 [33%]), CD5 (3/65 [5%]), and CD10 (1/38 [3%]). These results show that the immunophenotype of LPL/WM is variable and overlaps with other B-cell lymphoproliferative disorders. CD23, usually of dim intensity, and CD11c are expressed commonly in LPL/WM. Rare CD5+ and CD10+ cases of LPL/WM also exist.
Authors:
Sergej Konoplev; L Jeffrey Medeiros; Carlos E Bueso-Ramos; Jeffrey L Jorgensen; Pei Lin
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  124     ISSN:  0002-9173     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-29     Completed Date:  2005-10-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  414-20     Citation Subset:  AIM; IM    
Affiliation:
Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Antigens, CD / analysis
Antigens, CD5 / analysis
Antigens, Neoplasm / analysis
Female
Glycoproteins / analysis
Humans
Immunophenotyping
Leukemia, Lymphocytic, Chronic, B-Cell / immunology*,  pathology
Male
Middle Aged
Neprilysin / analysis
Receptors, IgE / analysis
Retrospective Studies
Waldenstrom Macroglobulinemia / immunology*,  pathology
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, CD5; 0/Antigens, Neoplasm; 0/CD52 antigen; 0/Glycoproteins; 0/Receptors, IgE; EC 3.4.24.11/Neprilysin

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