Document Detail


Immunophenotypic and genotypic analysis in cutaneous lymphoid hyperplasias.
MedLine Citation:
PMID:  8445059     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The clinical utility of immunophenotyping and Southern blot analysis in the evaluation of patients with cutaneous lymphoid hyperplasia (CLH) is controversial. OBJECTIVE: Our purpose was to determine whether adjunctive immunophenotyping and Southern blot analysis are of diagnostic and prognostic value in patients with CLH. METHODS: Immunophenotyping was performed on skin biopsy specimens from 26 patients with a routine histologic diagnosis of CLH. Southern blot analysis for immunoglobulin (Ig) gene rearrangements was done on 13 of 26 cases. RESULTS: Twenty-four of 26 patients had polyclonal CLH on immunophenotyping: 2 of 26 had monoclonal lymphoma. Two of 11 patients with polyclonal CLH studied by Southern blot analysis had clonal Ig gene rearrangements. In both, lymphoma developed within 1 to 6 years; comparison of CLH and malignant lymphoma demonstrated overlapping and different clonal bands. Two additional patients with polyclonal CLH developed lymphoma. No clonal gene rearrangements were detected in the CLH or lymphoma from one; the other was not studied. CONCLUSION: Immunophenotyping will identify some patients with lymphoma with nondiagnostic histologic features. Southern blot analysis will predict some patients with polyclonal CLH in whom malignant lymphoma will develop and who may benefit from definitive therapy.
Authors:
E Hammer; O Sangueza; P Suwanjindar; C R White; R M Braziel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  28     ISSN:  0190-9622     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-04-08     Completed Date:  1993-04-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  426-33     Citation Subset:  IM    
Affiliation:
Department of Pathology, Oregon Health Sciences University 97201.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blotting, Southern
Gene Rearrangement
Genes, Immunoglobulin
Genotype*
Humans
Hyperplasia
Immunophenotyping*
Lymphocytes / immunology*
Lymphoma / genetics,  immunology,  pathology
Middle Aged
Skin Diseases / genetics*,  immunology*,  pathology
Skin Neoplasms / genetics,  immunology,  pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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