| Immunophenotype of multinucleated and mononuclear cells in giant cell lesions of bone and soft tissue. | |
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MedLine Citation:
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PMID: 1597517 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To compare the antigenic phenotype of giant cells in giant cell lesions of bone and soft tissue with that of osteoclasts and macrophage polykaryons. METHODS: Formalin fixed, paraffin wax embedded sections of 106 giant cell lesions, 19 granulomatous, and 14 osteoclast containing lesions were immuno-histochemically stained for leucocyte common antigen (LCA), CD68, and HLA-DR. RESULTS: Osteoclasts and giant cells of giant cell tumour of bone and giant cell reparative granuloma could be distinguished by their generalised absence of HLA-DR reaction from macrophage polykaryons and giant cells in other giant cell lesions of bone and soft tissue. Staining for LCA, CD68, and HLA-DR was useful in distinguishing reactive histiocytic giant cells and osteoclasts from tumour giant cells. CONCLUSIONS: A panel of macrophage associated antigens should be diagnostically useful in differentiating the histological nature of giant cells in various giant cell lesions of bone and soft tissue. |
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Authors:
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I A Doussis; B Puddle; N A Athanasou |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of clinical pathology Volume: 45 ISSN: 0021-9746 ISO Abbreviation: J. Clin. Pathol. Publication Date: 1992 May |
Date Detail:
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Created Date: 1992-07-07 Completed Date: 1992-07-07 Revised Date: 2010-09-09 |
Medline Journal Info:
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Nlm Unique ID: 0376601 Medline TA: J Clin Pathol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 398-404 Citation Subset: AIM; IM |
Affiliation:
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Nuffield Department of Pathology and Bacteriology, John Radcliffe Hospital, Oxford. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bone Diseases
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immunology,
pathology Bone Neoplasms / immunology*, pathology Giant Cells / immunology* HLA-DR Antigens / analysis Humans Immunoenzyme Techniques Immunophenotyping Macrophages / immunology* Osteoclasts / immunology* Soft Tissue Neoplasms / immunology*, pathology |
| Chemical | |
Reg. No./Substance:
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0/HLA-DR Antigens |
| Comments/Corrections | |
Comment In:
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J Clin Pathol. 1993 Feb;46(2):190-1
[PMID:
8459047
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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