| Immunophenotype of vitamin D receptor polymorphism associated to risk of HIV-1 infection and rate of disease progression. | |
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MedLine Citation:
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PMID: 20642435 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vitamin-D-receptor (VDR) mediates immunomodulatory effects of vitamin-D₃ (VD₃). The VDR-rs1544410_GG polymorphism has been associated with delayed progression rates to AIDS and resistance to HIV-1 infection. The aim of the present study was to investigate differences in VD₃ mediated effects on rs1544410 genotyped dendritic cells (DCs) and macrophages (MDM), key cells involved in HIV-1 infection. Immature DCs exhibited lower b-actin-normalized VDR mRNA expression in rs1544410_GG compared to cells with a rs1544410_AA genotype. VD₃ response on cell differentiation markers (CD14 inhibition and CD209 induction) was two-fold higher in rs1544410_AA (CD209, p=0.012; CD14, p=0.02). HIV-1-LTR reporter gene activity in MDM was boosted by VD₃; however, the effect was up to 50% higher in rs1544410_AA. We conclude that the rs1544410_AA association with progression to AIDS and resistance to HIV-1 appears to be linked to an enhanced response to VD₃. |
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Authors:
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Carmen Torres; Manuel Sánchez de la Torre; Carelia García-Moruja; Antonio José Carrero; María del Monte Trujillo; Joan Fibla; Antonio Caruz |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Current HIV research Volume: 8 ISSN: 1873-4251 ISO Abbreviation: Curr. HIV Res. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-27 Completed Date: 2011-02-22 Revised Date: 2012-02-10 |
Medline Journal Info:
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Nlm Unique ID: 101156990 Medline TA: Curr HIV Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 487-92 Citation Subset: IM |
Affiliation:
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Dpto. de Biología Experimental, Universidad de Jaén, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cholecalciferol
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metabolism Dendritic Cells / immunology*, metabolism Disease Progression Genes, Reporter Genetic Predisposition to Disease* HIV Infections / genetics*, immunology*, virology HIV Long Terminal Repeat HIV-1 / physiology Humans Immunophenotyping Macrophages / immunology*, metabolism Polymorphism, Single Nucleotide* Receptors, Calcitriol / genetics* Signal Transduction Spain |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Calcitriol; 67-97-0/Cholecalciferol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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