Document Detail

Immunophenotype of myxopapillary ependymomas.
MedLine Citation:
PMID:  23455181     Owner:  NLM     Status:  MEDLINE    
Myxopapillary ependymoma (MPE) is a slow-growing tumor occurring almost exclusively in the region of conus medullaris, cauda equina, and filum terminale. On microscopic examination, some of these tumors show solid sheets of cells with an epithelioid morphology mimicking a metastatic carcinoma. Several immunohistochemical studies addressed this issue with discordant results. We report the immunohistochemical findings of 9 additional cases of MPE. From 2004 to 2011, a total of 9 cases of MPE were recorded in our surgical pathology files. The histologic material and clinical data were reviewed for each case. There were 6 female and 3 male patients. The ages ranged from 15 to 58 years (mean, 31 y). Eight cases were intradural, lumbosacral (L1-S1), and 1 case was located in the sacrum. All tumors expressed CD99 and GFAP (100%). Eight tumors were positive for CD56 (89%). All tumors (100%) expressed focally CKAE1/AE3. One tumor (11%) was focally positive for CK8/18 and CK7. D2-40 was focally positive in 1 case (11%). PLAP and AFP were both negative in all cases. Synaptophysin was focally positive in 1 case. NSE was positive in all cases. All tumors were negative for CK5/6, CK20, E-cadherin, and TTF-1. Our study shows that the vast majority of MPE are positive for CD99, CD56, and GFAP. In selective cases, especially when the material obtained for pathologic evaluation is scanty and the tumor displays epithelioid appearance, the diagnosis may be challenging owing to cytokeratin positivity suggesting metastatic carcinoma. However, the clinical and radiologic features in addition to the positivity for GFAP should prompt pathologists to consider MPE in the differential diagnosis of such cases. Interestingly, we found that MPE are positive for NSE, which suggests a neuroglial differentiation.
Ihab Lamzabi; Leonidas D Arvanitis; Vijaya B Reddy; Pincas Bitterman; Paolo Gattuso
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry     Volume:  21     ISSN:  1533-4058     ISO Abbreviation:  Appl. Immunohistochem. Mol. Morphol.     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2013-11-13     Completed Date:  2014-06-10     Revised Date:  2014-08-01    
Medline Journal Info:
Nlm Unique ID:  100888796     Medline TA:  Appl Immunohistochem Mol Morphol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  485-9     Citation Subset:  IM    
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MeSH Terms
Antigens, CD / genetics
Carcinoma / diagnosis
Cell Adhesion Molecules / genetics
Diagnosis, Differential
Ependymoma / diagnosis,  genetics,  pathology*
Glial Fibrillary Acidic Protein / genetics
Middle Aged
Peripheral Nervous System Neoplasms / diagnosis,  genetics,  pathology*
Phosphopyruvate Hydratase / genetics
Tumor Markers, Biological / genetics
Reg. No./Substance:
0/Antigens, CD; 0/CD99 protein, human; 0/Cell Adhesion Molecules; 0/Glial Fibrillary Acidic Protein; 0/Tumor Markers, Biological; EC Hydratase

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