Document Detail


Immunopharmacological studies using 5-hydroxytryptamine antibody.
MedLine Citation:
PMID:  1151746     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An antibody to serotonin (5-HT) was tested on several preparations in which 5-HT is considered to be involved. The antibody was capable of effectively competing with 5-HT receptor sites for free molecules of 5-HT. It inhibited the uptake of 3H-5HT by blood platelets and may explain the reduced endogenous 5-HT concentration in blood platelets of immunized rabbits. The decreased platelet content of 5-HT was substantiated by electron microscopic studies which showed a reduction in the number of 5-HT-containing subcellular storage organelles in platelets from these animals. The 5-HT antibody inhibited the 5-HT-induced contraction of aortic strips in a tissue bath preparation. When given intraventricularly, it inhibited for a time the sedative actions of reserpine thus adding new evidence to the often postulated role of 5-HT in the actions of reserpine.
Authors:
R A O'Brien; M Boublik; S Spector
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pharmacology and experimental therapeutics     Volume:  194     ISSN:  0022-3565     ISO Abbreviation:  J. Pharmacol. Exp. Ther.     Publication Date:  1975 Jul 
Date Detail:
Created Date:  1975-10-30     Completed Date:  1975-10-30     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0376362     Medline TA:  J Pharmacol Exp Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  145-53     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenylate Cyclase / immunology
Animals
Antibodies*
Binding, Competitive
Blood Platelets / metabolism,  ultrastructure
Dose-Response Relationship, Drug
Male
Microscopy, Electron
Myocardial Contraction / drug effects
Rabbits
Rats
Reserpine / antagonists & inhibitors
Serotonin / administration & dosage,  immunology*,  metabolism
Chemical
Reg. No./Substance:
0/Antibodies; 50-55-5/Reserpine; 50-67-9/Serotonin; EC 4.6.1.1/Adenylate Cyclase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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