| Immunopharmacological studies using 5-hydroxytryptamine antibody. | |
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MedLine Citation:
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PMID: 1151746 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An antibody to serotonin (5-HT) was tested on several preparations in which 5-HT is considered to be involved. The antibody was capable of effectively competing with 5-HT receptor sites for free molecules of 5-HT. It inhibited the uptake of 3H-5HT by blood platelets and may explain the reduced endogenous 5-HT concentration in blood platelets of immunized rabbits. The decreased platelet content of 5-HT was substantiated by electron microscopic studies which showed a reduction in the number of 5-HT-containing subcellular storage organelles in platelets from these animals. The 5-HT antibody inhibited the 5-HT-induced contraction of aortic strips in a tissue bath preparation. When given intraventricularly, it inhibited for a time the sedative actions of reserpine thus adding new evidence to the often postulated role of 5-HT in the actions of reserpine. |
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Authors:
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R A O'Brien; M Boublik; S Spector |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of pharmacology and experimental therapeutics Volume: 194 ISSN: 0022-3565 ISO Abbreviation: J. Pharmacol. Exp. Ther. Publication Date: 1975 Jul |
Date Detail:
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Created Date: 1975-10-30 Completed Date: 1975-10-30 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376362 Medline TA: J Pharmacol Exp Ther Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 145-53 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenylate Cyclase
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immunology Animals Antibodies* Binding, Competitive Blood Platelets / metabolism, ultrastructure Dose-Response Relationship, Drug Male Microscopy, Electron Myocardial Contraction / drug effects Rabbits Rats Reserpine / antagonists & inhibitors Serotonin / administration & dosage, immunology*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 50-55-5/Reserpine; 50-67-9/Serotonin; EC 4.6.1.1/Adenylate Cyclase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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