Document Detail


Immunoperoxidase localization of human papillomavirus in laryngeal papillomas.
MedLine Citation:
PMID:  6263818     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Five antigenically distinct serotypes of human papillomavirus (HPV) cause various cutaneous verrucae with distinct clinical features. Laryngeal and other mucosal papillomas, also suspected to have a viral etiology, were examined for the presence of a genus-specific (common) antigen of HPV using a peroxidase-antiperoxidase (PAP) technique. The primary antiserum used was reactive against laryngeal papillomas from 26 of 35 randomly selected patients (74%); overall, 49 of the 102 squamous papillomas stained were positive for HPV (48%). HPV antigen was not demonstrated within frankly dysplastic squamous cells. Nuclear localization of virus was confirmed by electron microscopy in 3 cases positive for HPV. PAP localization of HPV is rapid and more efficient than routine electron microscopy. Our data indicate a common pathogenesis for some papillomas and cutaneous verrucae and suggest a future role for immunohistochemistry in evaluating the epidemiology and pathobiology of laryngeal papillomatosis.
Authors:
E E Lack; A B Jenson; H G Smith; G B Healy; F Pass; G F Vawter
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Intervirology     Volume:  14     ISSN:  0300-5526     ISO Abbreviation:  Intervirology     Publication Date:  1980  
Date Detail:
Created Date:  1981-08-10     Completed Date:  1981-08-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0364265     Medline TA:  Intervirology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  148-54     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antigens, Viral / analysis
Humans
Immunoenzyme Techniques
Inclusion Bodies, Viral / ultrastructure
Laryngeal Neoplasms / microbiology*
Microscopy, Electron
Papilloma / microbiology*
Papillomaviridae / immunology*
Chemical
Reg. No./Substance:
0/Antigens, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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