Document Detail

Immunoperoxidase localization of human papillomavirus in laryngeal papillomas.
MedLine Citation:
PMID:  6263818     Owner:  NLM     Status:  MEDLINE    
Five antigenically distinct serotypes of human papillomavirus (HPV) cause various cutaneous verrucae with distinct clinical features. Laryngeal and other mucosal papillomas, also suspected to have a viral etiology, were examined for the presence of a genus-specific (common) antigen of HPV using a peroxidase-antiperoxidase (PAP) technique. The primary antiserum used was reactive against laryngeal papillomas from 26 of 35 randomly selected patients (74%); overall, 49 of the 102 squamous papillomas stained were positive for HPV (48%). HPV antigen was not demonstrated within frankly dysplastic squamous cells. Nuclear localization of virus was confirmed by electron microscopy in 3 cases positive for HPV. PAP localization of HPV is rapid and more efficient than routine electron microscopy. Our data indicate a common pathogenesis for some papillomas and cutaneous verrucae and suggest a future role for immunohistochemistry in evaluating the epidemiology and pathobiology of laryngeal papillomatosis.
E E Lack; A B Jenson; H G Smith; G B Healy; F Pass; G F Vawter
Related Documents :
3041568 - Bioapplication of colloidal gold in microbiological immunocytochemistry.
18827478 - Effects of fixative and embedding medium on morphology and immunostaining of the cochlea.
23403818 - Ny-eso-1 antibody as a novel tumour marker of gastric cancer.
78928 - Comparison of immunofluorescence and immunoperoxidase staining for identification of ru...
6497778 - Acquired paternal influence in mice. altered serum antibody response in the progeny pop...
17171758 - Helper function of cytolytic lymphocytes: switching roles in the immune response.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Intervirology     Volume:  14     ISSN:  0300-5526     ISO Abbreviation:  Intervirology     Publication Date:  1980  
Date Detail:
Created Date:  1981-08-10     Completed Date:  1981-08-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0364265     Medline TA:  Intervirology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  148-54     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antigens, Viral / analysis
Immunoenzyme Techniques
Inclusion Bodies, Viral / ultrastructure
Laryngeal Neoplasms / microbiology*
Microscopy, Electron
Papilloma / microbiology*
Papillomaviridae / immunology*
Reg. No./Substance:
0/Antigens, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Altered caudate nucleus field potentials following sustained stimulation to different substantia nig...
Next Document:  Immunoperoxidase antibody to human cytomegalovirus-induced membrane antigen assay in the absence of ...