| Immunopathology of nephropathies associated with malaria. | |
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MedLine Citation:
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PMID: 1083308 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Immune complexes play an important role in the pathogenesis of malaria-associated nephropathies. Two main types of lesion are demonstrable: (a) acute (transient-reversible) lesions typical of falciparum infections in man, with mild clinical symptoms developing a week or two after infection. Renal biopsies at that time show deposits of immunoglobulins, complement, and sometimes antigen. The lesions respond to antimalarials. (b) Chronic (progressive) lesions characteristic of quartan infections in man, developing slowly into a chronic stage with persistent proteinuria and gradually deteriorating renal function and hypertension. Renal biopsies at the onset of the disease show deposits of immunoglobulins, complement, and P. malariae antigens in glomerular capillary walls. Antimalarial therapy has no effect. Recent immunochemical findings confirm that these lesions are of the immune-complex type and are associated with malaria infection. However, several questions remain to be solved. |
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Authors:
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V Houba |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bulletin of the World Health Organization Volume: 52 ISSN: 0042-9686 ISO Abbreviation: Bull. World Health Organ. Publication Date: 1975 |
Date Detail:
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Created Date: 1976-07-06 Completed Date: 1976-07-06 Revised Date: 2010-10-26 |
Medline Journal Info:
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Nlm Unique ID: 7507052 Medline TA: Bull World Health Organ Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 199-207 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antigen-Antibody Complex* Child Humans Kidney / pathology* Kidney Diseases / etiology, immunology*, pathology Malaria / complications*, pathology Plasmodium / immunology |
| Chemical | |
Reg. No./Substance:
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0/Antigen-Antibody Complex |
| Comments/Corrections | |
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