| Immunopathological mechanisms underlying the time-course of Trichinella spiralis cardiomyopathy in rats. | |
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MedLine Citation:
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PMID: 9532006 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study shows that isolated, perfused hearts from rats orally infected with Trichinella spiralis have a reduced left ventricular developed pressure (LVDP), heart rate (HR) and coronary flow (CF). This reduction is considerably enhanced by a single bolus (100 pM) of PAF (platelet activating factor, an eosinophil activator), especially at 21 days post-infection (d.p.i.), which is the time of the maximum increase in blood and tissue eosinophilia. Helminthic DNA analysis shows that, from 21 d.p.i. onwards, the morphological and functional changes in the myocardium cannot be ascribed to the parasite's presence, whereas its antigens and the attendant immunopathological reactions might have a role in the induction of myocardial damage and dysfunction. Some perivascular inflammatory cells (eosinophils and mast cells) appear to undergo degranulation. All these data suggest a complex sequence of events, from acute myocarditis (21 d.p.i.) which may lead in time (48 d.p.i. onwards) to a dilating cardiomyopathy. |
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Authors:
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N Paolocci; M Sironi; M Bettini; G Bartoli; S Michalak; C Bandi; F Magni; F Bruschi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Virchows Archiv : an international journal of pathology Volume: 432 ISSN: 0945-6317 ISO Abbreviation: Virchows Arch. Publication Date: 1998 Mar |
Date Detail:
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Created Date: 1998-04-21 Completed Date: 1998-04-21 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9423843 Medline TA: Virchows Arch Country: GERMANY |
Other Details:
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Languages: eng Pagination: 261-6 Citation Subset: IM |
Affiliation:
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Istituto di Patologia Generale, Università di Perugia, Policlinico Monteluce, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiomyopathy, Dilated / immunology*, parasitology, pathology* DNA, Helminth / blood Heart Rate Immunohistochemistry Male Polymerase Chain Reaction Rats Rats, Sprague-Dawley Time Factors Trichinella spiralis / genetics, immunology* Trichinellosis / immunology, pathology*, physiopathology Ventricular Function, Left |
| Chemical | |
Reg. No./Substance:
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0/DNA, Helminth |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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