Document Detail

Immunopathological findings in posterior scleritis.
MedLine Citation:
PMID:  7797388     Owner:  NLM     Status:  MEDLINE    
Posterior scleritis can present with a variety of symptoms, and its clinical diagnosis is therefore difficult. Little is known about the pathogenesis and the cellular effector mechanisms. This case report presents the immunopathological findings of posterior scleritis in the enucleated eye of a 28-year-old female with no known underlying disease. The cells infiltrating the scleral fibers consisted predominantly of T cells. Many of them were CD4 cells. Clusters of T and B cells were found in perivascular areas. No signs of primary vasculitis were seen. The cellular infiltrate in posterior scleritis shows features compatible with a T-cell-mediated (autoimmune) disorder.
W Bernauer; E R Büchi; B Daicker
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  International ophthalmology     Volume:  18     ISSN:  0165-5701     ISO Abbreviation:  Int Ophthalmol     Publication Date:    1994-1995
Date Detail:
Created Date:  1995-07-31     Completed Date:  1995-07-31     Revised Date:  2006-07-19    
Medline Journal Info:
Nlm Unique ID:  7904294     Medline TA:  Int Ophthalmol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  229-31     Citation Subset:  IM    
University Eye Hospital, Basel, Switzerland.
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MeSH Terms
Autoimmune Diseases / immunology*,  pathology*
B-Lymphocytes / immunology
Eye Enucleation
Immunity, Cellular
Immunoenzyme Techniques
Sclera / immunology,  pathology
Scleritis / immunology*,  pathology*
T-Lymphocyte Subsets / immunology

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