Document Detail

Immunopathological diagnosis of cicatricial pemphigoid with desquamative gingivitis. A case report.
MedLine Citation:
PMID:  11288799     Owner:  NLM     Status:  MEDLINE    
Cicatricial pemphigoid (CP) is a chronic subepidermal bullous dermatosis which primarily involves the mucous membranes. The oral cavity and the eye are most frequently involved. Since extension of the lesion into the pharynx and esophagus causes sore throat and dysphagia and progressive ocular lesions may cause blindness, early and valid diagnosis is very important. Here we present a case of cicatricial pemphigoid with onset at age 45 in a patient who manifested severe periodontal disease and showed the lesion on the mucous membranes of the mouth (desquamative gingivitis), skin, and eyes. Since definite diagnosis is very important, we describe how we made a differential diagnosis from other diseases which also accompany desquamative gingivitis. We examined the clinical manifestations, blood test results, HLA-genotype, histopathologic findings of the affected tissue, and immunological findings in relation to autoimmunity. Since many of the CP cases are first referred to periodontists or dentists, we believe that the diagnostic strategy described in the present study will be quite informative for making rapid and definite diagnoses of similar cases.
M Kurihara; F Nishimura; T Hashimoto; A Komai; H Ueda; S Kokeguchi; S Takashiba; Y Murayama
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of periodontology     Volume:  72     ISSN:  0022-3492     ISO Abbreviation:  J. Periodontol.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-04-05     Completed Date:  2001-05-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8000345     Medline TA:  J Periodontol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  243-9     Citation Subset:  D; IM    
Department of Periodontology and Endodontology, Okayama University Dental School, Japan.
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MeSH Terms
Antibodies, Bacterial / blood
Autoimmune Diseases / diagnosis
Conjunctivitis / diagnosis,  immunology
Diagnosis, Differential
Fluorescent Antibody Technique, Direct
Gingivitis / diagnosis*,  immunology
HLA Antigens / analysis,  genetics
Immunoglobulin G / blood
Middle Aged
Pemphigoid, Benign Mucous Membrane / diagnosis*,  immunology
Periodontitis / diagnosis,  immunology,  microbiology
Prevotella intermedia / immunology
Reg. No./Substance:
0/Antibodies, Bacterial; 0/HLA Antigens; 0/Immunoglobulin G

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