| The immunopathological spectrum of crescentic glomerulonephritis: a survey of 106 patients in a single Chinese center. | |
| | |
MedLine Citation:
|
PMID: 20502041 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
BACKGROUND: Crescentic glomerulonephritis (CrGN) is a severe form of glomerular injury. We retrospectively analyzed data from Chinese patients with CrGN in our center to characterize the immunopathological spectrum of CrGN. METHODS: A total of 106 consecutive patients with biopsy-proven CrGN were recruited. CrGN was classified into 3 types according to findings on immunofluorescence microscopy; type I was defined as a linear deposition of immunoglobulins along the glomerular basement membrane (GBM), type II as a glomerular deposition of immune-complex and type III as a pauci-immune deposition. RESULTS: A total of 17/106 (16.0%) patients were classified as type I, 43/106 (40.6%) as type II and 46/106 (43.4%) as type III. Serum antineutrophil cytoplasmic antibodies (ANCA) could be detected in 1/17 (5.9%) patient with type I, 11/43 (25.6%) patients with type II and 29/46 (63.0%) patients with type III CrGN (p < 0.001). Serum anti-GBM antibodies could be detected in 14/17 (82.4%) patients with type I, 2/43 (4.7%) patients with type II and 3/46 (6.5%) patients with type III. In type II CrGN, ANCA-positive patients were older (p < 0.001), had more multi-system involvement (p < 0.001) and more fibrinoid necrosis in renal histopathology than ANCA-negative patients (p = 0.003). CONCLUSIONS: Pauci-immune CrGN might be the most common type of CrGN in Northern China. There was much heterogeneity within each type of CrGN. |
| | |
Authors:
|
Wei Lin; Min Chen; Zhao Cui; Ming-Hui Zhao |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-21 |
Journal Detail:
|
Title: Nephron. Clinical practice Volume: 116 ISSN: 1660-2110 ISO Abbreviation: Nephron Clin Pract Publication Date: 2010 |
Date Detail:
|
Created Date: 2010-08-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101159763 Medline TA: Nephron Clin Pract Country: Switzerland |
Other Details:
|
Languages: eng Pagination: c65-74 Citation Subset: IM |
Affiliation:
|
Renal Division, Department of Medicine, Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, Peking University First Hospital, Peking University, Beijing, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pulse wave velocity measurements are reproducible in multiple trained observers: a short report.
Next Document: Estimated lean body mass is more appropriate than body surface area for scaling glomerular filtratio...