| Immunopathologic study of erythema dyschromicum perstans (ashy dermatosis). | |
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MedLine Citation:
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PMID: 16911378 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Erythema dyschromicum perstans (EDP) is a pigmentary disease of unknown etiology in which damage to basal cells is thought to be mediated by adhesion molecules. The aim of this study was to characterize the histopathology and immunopathology of EDP. Forty-three patients from Medellín, Colombia, with the diagnosis of EDP were evaluated. Skin biopsy specimens were obtained for histopathology and immunohistochemistry, using monoclonal antibodies directed against the following markers: CD4, CD8, CD56, CD1a, CD68, CLA, HLA-DR, ICAM-1 and LFA-1alpha. A dermal lymphocytic infiltrate was observed in all cases, with a perivascular location in 86%. Other histologic features included melanophages in all specimens, vacuolization of the basement membrane zone (BMZ) 58% and exocytosis of lymphocytes (53.5%). The mean number of total leukocytes was 1510 cells mm-2 of tissue. There was a predominance of CD8+ T lymphocytes in the dermis and HLA-DR+, ICAM-1+ keratinocytes in the epidermis. Exocytosis of cutaneous lymphocyte antigen (CLA)+cells was observed in areas of BMZ damage, suggesting that response to antigenic stimulation may play a role in the development of EDP. |
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Authors:
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Luz A Vásquez-Ochoa; Diana M Isaza-Guzmán; Beatriz Orozco-Mora; Rodrigo Restrepo-Molina; Judith Trujillo-Perez; Félix J Tapia |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of dermatology Volume: 45 ISSN: 0011-9059 ISO Abbreviation: Int. J. Dermatol. Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-08-16 Completed Date: 2007-01-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0243704 Medline TA: Int J Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 937-41 Citation Subset: IM |
Affiliation:
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Universidad Pontificia Bolivariana, and Hospital Pablo Tobón Uribe, Medellín, Colombia. gigonzal@epm.net.co |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Basement Membrane / immunology, metabolism, pathology Child Colombia Erythema / immunology*, metabolism, pathology* Female Humans Male Middle Aged Pigmentation Disorders / immunology*, metabolism, pathology* Retrospective Studies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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