| Immunopathogenesis of Vitiligo. | |
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MedLine Citation:
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PMID: 21334464 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Vitiligo is a common depigmenting disorder which may have devastating psychological and social consequences and is characterized by the presence of circumscribed white macules in the skin due to the destruction of melanocytes in the epidermis. Various hypotheses have been proposed to explain the pathomechanisms involved in this disease, and studies have shown the participation of autoimmune processes in the pathogenesis of vitiligo. Cellular and humoral immunity has been implicated in the development of vitiligo and their role continues to be investigated. Peripheral blood and skin biopsies of patients with vitiligo show that T-cells, mononuclear cells, various pro-inflammatory cytokines, and auto-antibodies can damage melanocytes. Further research is required to determine whether autoimmunity is the main mechanism of vitiligo or only a consequence. |
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Authors:
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Manuel Sandoval-Cruz; Mario García-Carrasco; Renán Sánchez-Porras; Claudia Mendoza-Pinto; Mario Jiménez-Hernández; Pamela Munguía-Realpozo; Alejandro Ruiz-Argüelles |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-17 |
Journal Detail:
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Title: Autoimmunity reviews Volume: - ISSN: 1873-0183 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101128967 Medline TA: Autoimmun Rev Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2010. Published by Elsevier B.V. |
Affiliation:
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Department of Dermatology, HGR 36, IMSS, Puebla, Mexico; Department of Internal Medicine, HGR 36, CMN Manuel Avila Camacho, IMSS, Puebla, Mexico. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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