Document Detail


Immunoparesis and outcome in measles.
MedLine Citation:
PMID:  66426     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In five children with measles who subsequently died and in one with measles in whom chronic bronchopneumonia developed (group A), immunosuppression was more pronounced during the acute rash (i.e., 3-20 days before death) than in six children with measles who recovered (group B). The absolute total lymphocyte-count (T and B cells) was significantly lower in group A. Mean serum-C3 was also lower in group A than in group B. There were no significant differences between the two groups for other complement factors or for serum-immunoglobulins. The mean phytohaemagglutinin stimulation index (S.I.) for lymphocytes from patients in group A resembled that in group B, although the S.I. in both groups was significantly lower than that in healthy controls. S.I.S were lowest in two patients who died. Counts of total white cells, neutrophils, null cells, and those with both B and T cell markers were not significantly different in groups A and B. The total lymphocyte-count (mean 2117 +/- S.E.M. 375 cells/mm3) in a further nineteen patients with measles who had died, studied retrospectively, was significantly lower than that (4487 +/- 540 cells/mm3) in twenty-seven patients with measles who recovered.
Authors:
H M Coovadia; A Wesley; P Brain; L G Henderson; A F Hallett; G H Vos
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Lancet     Volume:  1     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1977 Mar 
Date Detail:
Created Date:  1977-05-12     Completed Date:  1977-05-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  619-21     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Bronchopneumonia / etiology
Child, Preschool
Complement C3 / analysis,  deficiency
Complement C4 / analysis
Dysgammaglobulinemia / complications
Female
Humans
Immunoglobulin A
Immunoglobulins / analysis
Immunologic Deficiency Syndromes / complications
Infant
Leukocyte Count
Lymphocyte Activation
Lymphocytes / immunology,  pathology
Lymphopenia / complications
Male
Measles / complications,  immunology*,  mortality
Retrospective Studies
Chemical
Reg. No./Substance:
0/Complement C3; 0/Complement C4; 0/Immunoglobulin A; 0/Immunoglobulins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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