| Immunoneutralization of procalcitonin or its component peptides: a promising treatment of sepsis. | |
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MedLine Citation:
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PMID: 20649514 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sepsis and the severe systemic response syndrome are very common illnesses that are responsible for a great amount of morbidity and death. These closely related conditions are characterized by a remarkable increase in the prohormone ProCT (procalcitonin). ProCT is both a marker of sepsis and a harmful mediator of the disease. In the present issue of Clinical Science, in a study in rats with endotoxin shock, Tavares and Miñano used an antibody to a segment of N-ProCT (aminoprocalcitonin) that is part of the ProCT molecule, and confirmed that immunoneutralization of ProCT saves the animals from this severe illness. Furthermore, they extensively studied the epiphenomena associated with this immunoneutralization. |
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Authors:
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Kenneth L Becker |
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Publication Detail:
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Type: Comment; Journal Article |
Journal Detail:
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Title: Clinical science (London, England : 1979) Volume: 119 ISSN: 1470-8736 ISO Abbreviation: Clin. Sci. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-10-20 Completed Date: 2011-01-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7905731 Medline TA: Clin Sci (Lond) Country: England |
Other Details:
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Languages: eng Pagination: 515-7 Citation Subset: IM |
Affiliation:
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George Washington University and Veterans Affairs Medical Center, Washington, DC 20037, USA. drkbecker@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Markers / blood Calcitonin / blood, immunology* Humans Immunotherapy / methods* Protein Precursors / blood, immunology* Rats Sepsis / blood, therapy* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Protein Precursors; 56645-65-9/procalcitonin; 9007-12-9/Calcitonin |
| Comments/Corrections | |
Comment On:
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Clin Sci (Lond). 2010 Dec;119(12):519-34
[PMID:
20569200
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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