Document Detail


Immunomorphological changes in the rhesus monkey endometrium and decidua during the menstrual cycle and early pregnancy.
MedLine Citation:
PMID:  22784010     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PROBLEM: Throughout the reproductive cycle and into early pregnancy, the normal endometrium undergoes changes in a range of leukocytes, epithelia, stromal fibroblasts, and vascular structures caused by intersecting effects of hormone balance and embryo implantation. The direct investigation in humans of reproductive tract responses during normal and physiologically altered cycles is not practical or feasible. METHOD AND STUDY: The aim of this study was to define immunological and morphological changes through immunohistological and morphometric evaluation of the endometrium throughout the menstrual cycle and the decidua during early gestation in the rhesus monkey, a tractable experimental animal model.
RESULTS: A zone-dependent method for the immunohistological description of the rhesus uterine mucosa was established and showed that leukocyte infiltration, stromal cell decidualization, glandular and vascular responses were zone- and cell type-dependent, and changed throughout the cycle and early pregnancy. Morphological heterogeneity of uterine natural killer cells in the cycling endometrium and gestational decidua were consistent with the recent characterization of phenotypic subsets.
CONCLUSIONS: These data establish a morphological platform upon which to further study the regulation of endometrial responses to the hormonal mileau of pregnancy, the control of local leukocyte populations, and the responses to threatened pregnancy, infection, and inflammation.
Authors:
Gennadiy I Bondarenko; Maureen Durning; Thaddeus G Golos
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-07-11
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  68     ISSN:  1600-0897     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-12     Completed Date:  2013-02-05     Revised Date:  2014-05-09    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  309-21     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons A/S.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Movement
Decidua / blood supply,  cytology,  immunology*
Endometrium / blood supply,  cytology,  immunology*
Female
Humans
Immunohistochemistry
Killer Cells, Natural / immunology*
Lymphocyte Subsets / immunology*
Macaca mulatta
Menstrual Cycle / immunology*
Models, Animal
Pregnancy
Stromal Cells / immunology
Grant Support
ID/Acronym/Agency:
AI076731/AI/NIAID NIH HHS; HD37120-06A2/HD/NICHD NIH HHS; P51 OD011106/OD/NIH HHS; P51 RR000167/RR/NCRR NIH HHS; P51RR000167/P51OD011106/OD/NIH HHS; R01 HD037120/HD/NICHD NIH HHS; R01 RR021876/RR/NCRR NIH HHS; RR020141-01/RR/NCRR NIH HHS; RR021876/RR/NCRR NIH HHS; RR15459-01/RR/NCRR NIH HHS
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