| Immunomodulatory therapy for sepsis: an update. | |
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MedLine Citation:
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PMID: 22029521 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Currently the treatment mainstay of sepsis is early and appropriate antibiotic therapy, accompanied by aggressive fluid administration, the use of vasopressors when needed and the prompt initiation of measures to support each failing organ. Activated protein C and hydrocortisone, when used accordingly can affect mortality. As the pathophysiologic events that take place during sepsis are being elucidated, new molecules that target each step of those pathways are being tested. However, a lot of those molecules affect various mediators of the sepsis cascade including inflammatory cytokines, cellular receptors, nuclear transcription factors, coagulation activators and apoptosis regulators. Over the last decade, a multitude of clinical trials and animal studies have investigated strategies that aimed to restore immune homeostasis either by reducing inflammation or by stimulating the innate and adaptive immune responses. Antibiotics, statins and other molecules with multipotent immunomodulatory actions have also been studied in the treatment of sepsis. |
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Authors:
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Eirini Christaki; Panagiota Anyfanti; Steven M Opal |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Expert review of anti-infective therapy Volume: 9 ISSN: 1744-8336 ISO Abbreviation: Expert Rev Anti Infect Ther Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-10-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101181284 Medline TA: Expert Rev Anti Infect Ther Country: England |
Other Details:
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Languages: eng Pagination: 1013-33 Citation Subset: IM |
Affiliation:
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Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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