| Immunomodulatory therapy for ocular inflammatory disease: a basic manual and review of the literature. | |
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MedLine Citation:
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PMID: 16419419 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Corticosteroids are used as first-line treatment for many ocular inflammatory conditions. The risk of adverse effects, however, necessitates conversion to steroid-sparing immunomodulatory therapy (IMT) for disease that is recurrent, chronic, or poorly responsive to treatment. Combination drug treatments with multiple agent 'recipes' are also considered. Immunomodulatory agents include the broad categories of antimetabolites (azathioprine, methotrexate, mycophenolate mofetil), alkylating agents (cyclophosphamide, chlorambucil), T-cell inhibitors (cyclosporine, tacrolimus), and cytokines (interferon alfa). This article reviews and summarizes the evidence for IMT agent use in the treatment of various forms of ocular inflammation. |
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Authors:
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Annabelle A Okada |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Ocular immunology and inflammation Volume: 13 ISSN: 0927-3948 ISO Abbreviation: Ocul. Immunol. Inflamm. Publication Date: 2005 Sep-Oct |
Date Detail:
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Created Date: 2006-01-19 Completed Date: 2006-03-02 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9312169 Medline TA: Ocul Immunol Inflamm Country: Netherlands |
Other Details:
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Languages: eng Pagination: 335-51 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Kyorin University School of Medicine, 6-20-2, Shinkawa, Mitaka, Tokyo 181-8611, Japan. aokada@po.iijnet.or.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alkylating Agents
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therapeutic use Antimetabolites / therapeutic use Humans Immunologic Factors / therapeutic use* Immunosuppressive Agents / therapeutic use* Practice Guidelines as Topic Treatment Outcome Uveitis / drug therapy*, immunology |
| Chemical | |
Reg. No./Substance:
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0/Alkylating Agents; 0/Antimetabolites; 0/Immunologic Factors; 0/Immunosuppressive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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